You Searched For: ENZO LIFE SCIENCES

Supplier: ENZO LIFE SCIENCES

Description: HMG-CoA reductase inhibitor

Catalog Number: (ENZOBMLEI1550100)

Supplier: ENZO LIFE SCIENCES

Description: Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.

UOM: 1 * 100 mg

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Supplier: ENZO LIFE SCIENCES

Description: Nampt inhibitor

Supplier: ENZO LIFE SCIENCES

Description: Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

Catalog Number: (ENZOBMLEH0010001)

Supplier: ENZO LIFE SCIENCES

Description: Isolated from ram seminal vesicles.

UOM: 1 * 1 mg

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Supplier: ENZO LIFE SCIENCES

Description: Caspase-1 inhibitor

Catalog Number: (ENZOALX522052C010)

Supplier: ENZO LIFE SCIENCES

Description: Produced in HEK 293 cells. The extracellular domain of mouse BAFF (aa 127-309) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.

UOM: 1 * 10 µG

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Catalog Number: (ENZOALX522132C010)

Supplier: ENZO LIFE SCIENCES

Description: Produced in HEK 293 cells. Rat omentin (aa 20-313) is fused at the N-terminus to a FLAG®-tag.

UOM: 1 * 10 µG

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Supplier: ENZO LIFE SCIENCES

Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Catalog Number: (ENZOBMLSE1765000)

Supplier: ENZO LIFE SCIENCES

Description: Produced in <i>E. coli</i>.

UOM: 1 * 1 Vial

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Supplier: ENZO LIFE SCIENCES

Description: CDK inhibitor

Supplier: ENZO LIFE SCIENCES

Description: Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.

Supplier: ENZO LIFE SCIENCES

Description: Caspase-3 inhibitor

Supplier: ENZO LIFE SCIENCES

Description: Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).

Supplier: ENZO LIFE SCIENCES

Description: Prostanoid receptor ligand.

Supplier: ENZO LIFE SCIENCES

Description: A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).