FK-866 ≥98% (by NMR)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
(E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide, (E)-Daporinad
Nampt inhibitor
Selective inhibitor of the nicotinamide pathway dependent NAD+synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT/NAPRT) for both the enzyme/substrate complex and the free enzyme (Ki=0.4 nM and Ki´=0.3 nM, respectively). NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50=~1 nM). Causes premature senescence in normal human smooth muscle cells. Induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.
Synthetic.
Formula:
C₂₄H₂₉N₃O₂ MW: 391,5 g/mol |
MDL Number:
MFCD10565943 CAS Number: 658084-64-1 |
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