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Akt inhibitor VIII ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG
Description: Potent inhibitor of Akt1, Akt2 and Akt3 activity.

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Histone Deacetylase Inhibitor VIII ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES AG
Description: HDAC6 inhibitor

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Akt kinase activity kit

Catalog Number: (ENZOADIEKS400A)
Supplier: ENZO LIFE SCIENCES AG
Description: This is a non-radioactive Akt kinase activity assay, providing a safe, rapid and reliable method for the screening of inhibitors or activators of Akt and for quantitating the activity of Akt in purified or partially purified enzyme preparations. The Akt Kinase activity kit is based on a solid phase enzyme immunoassay (EIA) that utilizes a specific synthetic peptide as a substrate for Akt and a polyclonal antibody that recognizes the phosphorylated form of the substrate. The assay is designed for the analysis of Akt (1, 2, 3) activity in the solution phase.
UOM: 1 * 1 KIT

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SH-5

Supplier: ENZO LIFE SCIENCES AG
Description: Akt inhibitor

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Image Unavailable-ENZOENZCHM1260001

10-DEBC hydrochloride ≥98% (by HPLC)

Catalog Number: (ENZOENZCHM1260001)
Supplier: ENZO LIFE SCIENCES AG
Description: Selective inhibitor of Akt (PKB).
UOM: 1 * 1 mg

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Image Unavailable-ENZOENZCHM1390010

TG100115 ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG
Description: Inhibitor of PI3Kγ, PI3Kδ, FRAP, Akt and VEGF.

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Image Unavailable-ENZOBMLEI3320005

Triciribine ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG
Description: Akt inhibitor

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Image Unavailable-ENZOALX260155M001

PKCζ PseudoSubstrate

Catalog Number: (ENZOALX260155M001)
Supplier: ENZO LIFE SCIENCES AG
Description: Selective cell permeable inhibitor of PKCzeta. Activates eNOS (NOS III) through Akt phosphorylation and can be considered as a nitric oxide production activator in endothelial cells.
UOM: 1 * 1 mg

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Image Unavailable-ENZOADIKAPPK004F

Anti-AKT Rabbit Polyclonal Antibody

Supplier: ENZO LIFE SCIENCES AG
Description: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

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Image Unavailable-ENZOADI905773100

Anti-AKT Rabbit Polyclonal Antibody

Catalog Number: (ENZOADI905773100)
Supplier: ENZO LIFE SCIENCES AG
Description: The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified to date (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.
UOM: 1 * 100 µG

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Image Unavailable-J64554.MA

GSK-3β inhibitor VIII

Catalog Number: (J64554.MA)
Supplier: Thermo Scientific
Description: A cell-permeable, potent, and selective inhibitor of GSK-3beta.
UOM: 1 * 10 mg

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Image Unavailable-506163-5MG

p38 MAP Kinase Inhibitor VIII ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®

Catalog Number: (506163-5MG)
Supplier: Merck Millipore (Calbiochem‎)
Description: p38 MAP Kinase Inhibitor VIII ≥97% (by HPLC), Calbiochem®, Sigma-Aldrich®
UOM: 1 * 5 mg
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GW5074 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES AG
Description: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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Image Unavailable-ENZOALX350312M025

(-)-Arctigenin (from Arctium lappa) ≥97% (by HPLC)

Catalog Number: (ENZOALX350312M025)
Supplier: ENZO LIFE SCIENCES AG
Description: Lignan derivative, which shows antitumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic and cytotoxic properties against Hep62 cells.  Antagonist for platelet activating factor and Ca²⁺. Blocks the activation of Akt (protein kinase B; PKB) induced by glucose starvation.
UOM: 1 * 25 mg

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Image Unavailable-ENZOADI905643100

Anti-IGF1R Mouse Monoclonal Antibody [clone: 2B9]

Catalog Number: (ENZOADI905643100)
Supplier: ENZO LIFE SCIENCES AG
Description: Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes.
UOM: 1 * 100 µG

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Midostaurin ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES AG
Description: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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