Midostaurin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
PKC412, N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide
Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.
- Flt inhibitor
White to off-white powder.
Soluble in DMSO (15mg/ml), MDC (10mg/ml), methanol (5mg/ml) or 100% ethanol (2.5mg/ml).
Formula:
C₃₅H₃₀N₄O₄ MW: 570,64 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD12828879 CAS Number: 120685-11-2 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...