Triciribine ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: (2R,3R,4S,5R)-2-(3-Amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

BMLEI3320001 BMLEI3320005
ENZOBMLEI3320001EA 185 GBP
ENZOBMLEI3320001 ENZOBMLEI3320005
Triciribine ≥98% (by HPLC)
Triciribine

Akt inhibitor


Triciribine is a synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. It inhibits cell growth and induces apoptosis preferentially in cells that express aberrant Akt1. In whole cells triciribine is phosphorylated by adenosine kinase which may be necessary for its activity.

Formula: C₁₃H₁₆N₆O₄
MW: 320,303 g/mol
MDL Number: MFCD00932413
CAS Number: 35943-35-2
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