You Searched For: ENZO LIFE SCIENCES

Catalog Number: (ENZOENZ42843L0050)

Supplier: ENZO LIFE SCIENCES

Description: Gold 525 dUTP (lyophilised)

UOM: 1 * 50 Nmo

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Supplier: ENZO LIFE SCIENCES

Description: rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal.

Supplier: ENZO LIFE SCIENCES

Description: The EFLUXX-ID® Multidrug Resistance Assay Kit allows for functional detection of all three clinically relevant ABC transporter proteins MDR1 (p-glycoprotein), MRP1/2, and BCRP. The assay uses a hydrophobic, non-fluorescent compound that readily penetrates the cell membrane, where it is hydrolyzed to a hydrophilic fluorescent dye by intracellular esterases.

Supplier: ENZO LIFE SCIENCES

Description: Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase (Ki=109nM in the absence of AMP) in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. It has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6. Promotes cardiomyogenesis in mouse embryonic stem cells. Induces protective autophagy in cancer cell lines.

Supplier: ENZO LIFE SCIENCES

Description: delta-opioid receptor agonist

Catalog Number: (ENZOALX805041C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX260087M001)

Supplier: ENZO LIFE SCIENCES

Description: Fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes and for the proteasome.

UOM: 1 * 1 mg

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Catalog Number: (ENZOADI905759100)

Supplier: ENZO LIFE SCIENCES

Description: Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3.

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: Inhibits ATP-sensitive K+ channels.

Catalog Number: (ENZOBMLPI1250005)

Supplier: ENZO LIFE SCIENCES

Description: Cathepsin inhibitor

UOM: 1 * 5 mg

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Supplier: ENZO LIFE SCIENCES

Description: Host: Rabbit

Supplier: ENZO LIFE SCIENCES

Description: Potent and selective protein kinase C inhibitor which has been used effectively in platelets, Swiss 3T3 fibroblasts and macrophages. Inhibitory profile: PKC, IC50=0.02µM (inhibits α, ßI, ßII and γ subtypes with similar potency); PKA, IC50=2.0µM; phosphorylase kinase, IC50=0.7µM; insulin, EGF and PDGF receptor tyrosine kinases are not inhibited at concentrations up to 50µM.

Catalog Number: (ENZOALX430007M100)

Supplier: ENZO LIFE SCIENCES

Description: Stable nitric oxide (NO) radical scavenger.

UOM: 1 * 100 mg

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Catalog Number: (ENZOENZCHM1290005)

Supplier: ENZO LIFE SCIENCES

Description: Hedgehog (Hh) pathway blocker.

UOM: 1 * 5 mg

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Supplier: ENZO LIFE SCIENCES

Description: The ROS-ID® Hypoxia/Oxidative Stress Detection Kit is a specific detection system designed for functional detection of hypoxia and oxidative stress levels in live cells (both suspension and adherent) using fluorescent microscopy or flow cytometry.

Supplier: ENZO LIFE SCIENCES

Description: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.