You Searched For: SGE+Analytical+Science

Catalog Number: (ENZOBMLEI3650010)

Supplier: ENZO LIFE SCIENCES

Description: A selective inhibitor of MEK1 and MEK2 (IC50= 0.18 and 0.22 µM respectively). Displays neuroprotective effects against ischemic brain injury.

UOM: 1 * 10 mg

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Supplier: DWK Life Sciences

Description: Multi-functional glass wide mouth laboratory bottles with protective safety coating.

Supplier: ENZO LIFE SCIENCES

Description: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.

Supplier: ENZO LIFE SCIENCES

Description: Concentrated lysis buffer for preparation of cell and tissue extracts.

Supplier: ENZO LIFE SCIENCES

Description: Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Supplier: ENZO LIFE SCIENCES

Description: DnaK possesses an autophosphorylation activity and a weak 5-nucleotidase activity, cleaving the 5 phosphate groups from both ribose and deoxyribose nucleotides. The role of DnaK in ATP-dependent protein-protein interactions has been extended to normal E. coli physiology, where, like eukaryotic Hsp70 homologs, it is thought to participate in the assembly/disassembly of protein complexes.

Catalog Number: (ENZOALX430139M025)

Supplier: ENZO LIFE SCIENCES

Description: Topoisomerase I inhibitor

UOM: 1 * 25 mg

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Supplier: ENZO LIFE SCIENCES

Description: Most efficient spin trap for the <i>in vitro</i> and <i>in vivo</i> detection of O-, N-, S-, and C-centered free radicals.

Supplier: ENZO LIFE SCIENCES

Description: CaM kinase II inhibitor

Supplier: ENZO LIFE SCIENCES

Description: Bcl-2 ligand

Supplier: DWK Life Sciences

Description: DURAN® Original GL laboratory bottles have become the gold standard of multifunctional laboratory bottles since their introduction in 1972. The protect safety-coated version of the bottles combining the best of both worlds: virtually inert USP/EP Type I borosilicate glass 3.3 glass on the inside and a protective safety plastic layer on the outside.

New Product

Catalog Number: (ENZORLT-300-010)

Supplier: ENZO LIFE SCIENCES

Description: Human Recombinant HGF (from Insect cells)

UOM: 1 * 5 µG

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Supplier: MERCK LIFE SCIENCE

Description: The product range includes a full line of pre-poured 90 mm or 150 mm Petri dishes for a wide range of different applications, such as enumeration, isolation, detection and cultivation of bacteria as well as yeast and moulds. In order to choose the best packaging for each kind of use, both small packs of 20 plates and bulk packs of 100 plates are available for each kind of plate.

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Supplier: DWK Life Sciences

Description: These economical columns are constructed of polypropylene reservoirs and column outlets permanently connected to a borosilicate glass barrel, molded PP end caps, and HDPE bed supports. They also feature Luer lock inlet and outlet fittings for better connections.

Supplier: ENZO LIFE SCIENCES

Description: Cholesterol metabolite linked to breast cancer, neurodegenerative disease and metabolism.

Catalog Number: (ENZOENZC34933)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG2b

UOM: 1 * 0,5 mL

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