HA14-1 ≥95% (by 1H-NMR)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative)

ALX430101M005 ALX430101M025
ENZOALX430101M005EA 77.1 GBP
ENZOALX430101M005 ENZOALX430101M025
HA14-1 ≥95% (by 1H-NMR)
HA14-1

Bcl-2 ligand


Antagonizes the function of Bcl-2 and induces apoptosis. In HL-60 cells, HA4-1 (50 µM and 4 h incubation) induced apoptosis of more than 90% of the cells. Apoptosis is blocked by ZVAD-FM. IC₅₀= ~9 µM for competition with Flu-BakBH3 binding to Bcl-2.


Soluble in DMSO (25 mg/ml), dimethyl formamide or halogenated solvents; also soluble in 100% ethanol (25 mg, 7 ml hot).

Formula: C₁₇H₁₇BrN₂O₅
MW: 409,24 g/mol
Storage Temperature: Freezer
MDL Number: MFCD00218213
CAS Number: 65673-63-4

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Specification Test Results

Purity (¹H-NMR) ≥95%
Identity Identity determined by IR, ¹H-NMR
Appearance Off-white to light yellow powder

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