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Aurintricarboxylic acid ≥85%, powder, Practical grade for titration, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY

Description: Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.

Aurintricarboxylic acid

Supplier: Thermo Scientific

Description: Aurintricarboxylic acid

MSDS Certificates

Aluminon, powder, Sigma-Aldrich®

Catalog Number: (A0885-25G)

Supplier: SIGMA-ALDRICH MICROSCOPY

Description: Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.

UOM: 1 * 25 g

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Aluminon ACS, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY

Description: Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.