Aurintricarboxylic acid ≥85%, powder, Practical grade for titration, Sigma-Aldrich®
Supplier: SIGMA-ALDRICH MICROSCOPY
M-Clarity™ quality level = MQ300
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca²⁺ -impermeable GluR2 receptors and inhibits calpain, a Ca²⁺ -activated protease that is activated during apoptosis.
- Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum
- It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase)
- It has been used as a ribonuclease inhibitor
Formula:
C₂₂H₁₄O₉ MW: 422,35 g/mol Melting Pt: 300 °C (lit.) Storage Temperature: Room Temperature |
MDL Number:
MFCD00011663 CAS Number: 4431-00-9 EINECS: 224-628-1 |
Specification Test Results
Red to Very Dark Red and Red-Brown and Brown-Red | Appearance (Colour) |
Appearance (Form) | Powder |
Solubility (Colour) | Faint Orange to Red-Brown |
Solubility (Turbidity), 10 mg/mL, 1M NH4OH | Clear |
Infrared spectrum | Conforms to Structure |
Loss on Drying | ≤5 % |
Purity (Titration by NaOH) | ≥85 % |
Recommended Retest Period | 6 Years |
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