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You Searched For: 5-Fluorouracil


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Image Unavailable-8.18505.0005

5-Fluorouracil for synthesis, Sigma-Aldrich®

Catalog Number: (8.18505.0005)
Supplier: Merck
Description: 5-Fluorouracil for synthesis, Sigma-Aldrich®
UOM: 1 * 5 g

MSDS


Image Unavailable-F6627-10G

5-Fluorouracil ≥99% (by HPLC), powder, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY
Description: 5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitising agent. A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

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5-Fluorouracil

Supplier: Apollo Scientific
Description: This pyrimidine analogue, is an antineoplastic agent.

Product Image-228440010.

5-Fluorouracil 99%

Supplier: Thermo Scientific
Description: 5-Fluorouracil 99%

MSDS

Image Unavailable-03738-100MG

5-Fluorouracil, analytical standard, Supelco®

Catalog Number: (03738-100MG)
Supplier: Merck
Description: Organic Standard, 5-Fluorouracil
UOM: 1 * 100 mg
Image Unavailable-ENZOALX480099G005

5-Fluorouracil

Catalog Number: (ENZOALX480099G005)
Supplier: ENZO LIFE SCIENCES AG
Description: Thymidylate synthetase inhibitor
UOM: 1 * 5 g

New Product


Image Unavailable-PHR1227-500MG

Pharmaceutical secondary standard, Fluorouracil, (CRM), Supelco®

Catalog Number: (PHR1227-500MG)
Supplier: Merck
Description: Organic Standard, Fluorouracil
UOM: 1 * 500 mg
Image Unavailable-APOSPC4380-25G

5-Fluorouracil 99%

Supplier: Apollo Scientific
Description: Antineoplastic agent. Not USP. Not for drug use.

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5-Fluorouracil ≥99%

Supplier: Thermo Scientific
Description: 5-Fluorouracil ≥99%

MSDS Certificates

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O,O'-Bis(trimethylsilyl)-5-fluorouracil 97%

Supplier: Thermo Scientific
Description: O,O'-Bis(trimethylsilyl)-5-fluorouracil 97%

MSDS Certificates

Image Unavailable-APOSPC4054-25G

5-Fluoroorotic acid monohydrate (5-FOA) 98%

Supplier: Apollo Scientific
Description: Useful in the selection of orotidine-5'-phosphatedecarboxylase mutants in Saccharomycescerevisiae: Genetics, 1984, 107, 179.

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Fluorouracil, Reference Standards

Supplier: USP
Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Certificates

Image Unavailable-BOSSBS-8288R-A555

Anti-DPYD Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-8288R-A555)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8288R-HRP

Anti-DPYD Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-8288R-HRP)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
UOM: 1 * 100 µl
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Fluorouracil Related Compounds, Reference Standard

Supplier: USP
Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.

Product Image-ACRO462790050

5-Fluoro-5'-deoxyuridine (Doxifluridine)

Supplier: Thermo Scientific
Description: 5-Fluoro-5'-deoxyuridine (Doxifluridine)

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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