5-Fluorouracil ≥99% (by HPLC), powder, Sigma-Aldrich®

Supplier: SIGMA-ALDRICH MICROSCOPY
Danger

Synonyms: Fluorouracil, 5-Fluoropyrimidine-2,4(1H,3H)-dione, 5-FU

M-Clarity™ quality level = MQ200

F6627-1G F6627-10G F6627-5G
F6627-1GEA 30.2 GBP
F6627-1G F6627-10G F6627-5G
5-Fluorouracil ≥99% (by HPLC), powder, Sigma-Aldrich®
5-Fluorouracil

5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitising agent. A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

Formula: C₄H₃FN₂O₂
MW: 130,08 g/mol
Boiling Pt: 347 °C (1013 hPa)
Melting Pt: 282…286 °C (dec., lit.)
Storage Temperature: Room Temperature
MDL Number: MFCD00006018
CAS Number: 51-21-8
EINECS: 200-085-6
UN: 2811
ADR: 6.1,III
Merck Index: 13,04208
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Specification Test Results

Appearance (Colour) White to Off-White
Appearance (Form) Powder
Solubility (Colour) Colourless to Very Faint Yellow
Solubility (Turbidity), 50 mg per ml in 1 M Ammonium Hydroxide Clear
Infrared spectrum Conforms to Structure
Purity (HPLC) ≥99%
Recommended Retest Period 2 years

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