Necrostatin-1 ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: 5-((1H-Indol-3-yl)methyl)-3-methyl-2-thioxoimidazolidin-4-one, Nec-1

BMLAP3090020 BMLAP3090100
ENZOBMLAP3090020EA 127 GBP
ENZOBMLAP3090020 ENZOBMLAP3090100
Necrostatin-1 ≥98% (by TLC)
Necrostatin-1

Inhibits necroptosis


Necrostatin-1 inhibits necroptosis, a non-apoptotic cell death pathway. Inhibits the loss of mitochondrial membrane potential in TNFα-treated Jurkat cells (EC50=490 nM). Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. It displays a pronounced protective effect in a mouse model of ischemic brain injury and inhibits myocardial cell death. Inhibits RIP1 kinase the key upstream kinase involved in the activation of necroptosis (EC50=180nM).

Formula: C₁₃H₁₃N₃OS
MW: 259,327 g/mol
MDL Number: MFCD00056916
CAS Number: 4311-88-0

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