(S)-(+)-Camptothecin ≥98%
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, (+)-Camptothecin, 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Potent antitumor agent
Potent antitumor agent. Inhibitor of DNA-topoisomerase I. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cells. Inhinbits Tat-mediated transactivation of HIV-1. Induces apoptosis in osteosarcoma and hepatoma cells. Suppresses nitric oxide (NO) biosynthesis.
Isolated from Mappia foetida Miers (Nothapodytes foetida (Wt.) Sleumer).
Formula:
C₂₀H₁₆N₂O₄ MW: 348,36 g/mol |
MDL Number:
MFCD00081076 CAS Number: 7689-03-4 |
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