H-1152 dihydrochloride ≥98% (by HPLC)

Supplier: ENZO LIFE SCIENCES AG

Synonyms: (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulphonyl]homopiperazine 2HCl, H-1152P 2HCl

ALX270423M001 ALX270423M005 ALX270423M025
ENZOALX270423M001EA 87.1 GBP
ENZOALX270423M001 ENZOALX270423M005 ENZOALX270423M025
H-1152 dihydrochloride ≥98% (by HPLC)
H-1152 dihydrochloride

A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.


  • ROCK inhibitor


White to off-white solid.


Soluble in water.

Formula: C₁₆H₂₁N₃O₂S·2HCl
MW: 319,4 · 73,0 g/mol
Storage Temperature: Freezer
CAS Number: 45146-2-58-1

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