H-1152 dihydrochloride ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulphonyl]homopiperazine 2HCl, H-1152P 2HCl
A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.
- ROCK inhibitor
White to off-white solid.
Soluble in water.
Formula:
C₁₆H₂₁N₃O₂S·2HCl MW: 319,4 · 73,0 g/mol Storage Temperature: Freezer |
CAS Number:
45146-2-58-1 |
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