SB239063 ≥97% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazol-1-yl]cyclohexan-1-ol, trans-4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-cyclohexanol, Rel-(1r,4r)-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexan-1-ol, 4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexanol
A potent, cell permeable inhibitor of p38 MAP kinase (IC50=44nM for recombinant purified human p38α). Inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes (IC50=120nM and 350nM, respectively). Reported to protect against mild excitotoxic neuronal injury caused by NMDA and provides substantial protection against cell death induced by either oxygen glucose deprivation (OGD) or magnesium deprivation in cultured neurons. Also, reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of polymorphonuclear (PMN) accumulation.
- p38 inhibitor
White to off-white solid.
Soluble in DMSO, 100% ethanol or dichlormethane (may require slight warming).
Formula:
C₂₀H₂₁FN₄O₂ MW: 368,4 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD03792786 CAS Number: 193551-21-2 |
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