Gabexate mesylate ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]benzoic acid ethyl ester Mesylate, Ethyl 4-((6-guanidinohexanoyl)oxy)benzoate methanesulphonate, Gabexate Methanesulphonate
A competitive, reversible inhibitor of serine proteases tryptase (Ki=3.4nM), thrombin (Ki=500nM), uPA (Ki=1.3µM), plasmin (Ki=1.5µM), trypsin (Ki=2µM), factor Xa (Ki=2µM). At higher concentrations it inhibits kallikrein-1 (Ki=2.6mM), C1 esterase (IC50=520µM), as well as phospholipase A2 (IC50=500µM), rat iNOS (Ki=5mM) and cNOS (Ki=150µM), and swine kidney copper amine oxidase (Ki=27µM), but not chymotrypsin. Has been used in tissue culture and in vivo. In clinical use for pancreatitis.
- Protease inhibitor
White solid.
Soluble in water (25 mg/ml).
Formula:
C₁₆H₂₃N₃O₄·CH₃SO₃H MW: 417,5 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00210299 CAS Number: 56974-61-9 |
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