ICRF-193 ≥95% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
Meso-4,4'-(3,2-butanediyl)-bis(2,6-piperazinedione)
BMLGR3320001
BMLGR3320005
ENZOBMLGR3320001EA
143
GBP
ENZOBMLGR3320001
ENZOBMLGR3320005
ICRF-193 ≥95% (by HPLC)
ICRF-193
A topoisomerase II inhibitor that does not cause DNA damage. Induces apoptosis in several cell lines including K562 and Molt-4 cells. Induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.
- Topoisomerase inhibitor
Off-white to pale yellow solid.
Soluble in DMSO (4mg/ml).
Formula:
C₁₂H₁₈N₄O₄ MW: 282,3 g/mol Melting Pt: 298…299 °C Storage Temperature: Freezer |
CAS Number:
21416-68-2 |
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