MK-886 ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
3-(3-(tert-Butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid, L-663,536, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid Na
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
- FLAP inhibitor
White solid.
Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
Formula:
C₂₇H₃₃ClNO₂S·Na MW: 494,0 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00876710 CAS Number: 118414-82-7 |
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