N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)

Supplier: ENZO LIFE SCIENCES AG

BMLSL1050005 BMLSL1050025
ENZOBMLSL1050005EA 81.1 GBP
ENZOBMLSL1050005 ENZOBMLSL1050025
N,N-Dimethylsphingosine, D-erythro ≥98% (by TLC)
N,N-Dimethylsphingosine, D-erythro

Sphingosine kinase inhibitor


Potent and specific inhibitor of sphingosine kinase (IC50=5µM) which blocks conversion of sphingosine to sphingosine-1-phosphate (Prod. No. BML-SL140). Inhibitor of protein kinase C (PKC) which also stimulates Src-kinase. May affect expression of cell surface selectins, which in turn mediate leukocyte or tumor cell adhesion to endothelial cells and platelets. Induces apoptosis. Stereospecifically induces EGF receptor autophosphorylation producing EGF-like activity in vitro in the absence of EGF. Produced endogenously via ceramide catabolism. May be a target for neuropathic pain therapy.


Synthetic.

CAS Number: 119567-63-4
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