BX-795 ≥97% (by HPLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
BX795, N-(3-((5-Iodo-4-((3-(thiophene-2-carboxamido)propyl)amino)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide
Inhibitor of PDK1, TBK1, IKK-ε, IRF3
BX795 was initially developed as a PDK1 inhibitor (direct competitive inhibitor IC50 = 11nM for PDK1) and has been shown to be a potent and relatively specific inhibitor of TBK1 and IKK-ε. It blocks the phosphorylation, nuclear translocation, and transcriptional activity of interferon regulatory factor 3. BX795 also is a potent inhibitor of cell growth of multiple cancer cell lines with IC50 values ranging from submicromolar amounts (0.368 µM to greater than 450 µM).
Formula:
C₂₃H₂₆IN₇O₂S MW: 591,5 g/mol |
MDL Number:
MFCD12546134 CAS Number: 702675-74-9 |
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