Haloenol lactone suicide substrate ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
HELSS
HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).
- Phospholipase inhibitor
White solid.
Soluble in DMSO (25mg/ml).
Formula:
C₁₆H₁₃BrO₂ MW: 317,2 g/mol Melting Pt: 104…106 °C Storage Temperature: Freezer |
MDL Number:
MFCD00270871 CAS Number: 88070-98-8 |
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