PP1 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Src kinase inhibitor
A highly potent and selective inhibitor of Src family tyrosine kinases, IC50=5 nM for p56lck; p59fynT=6 nM; p60src=170 nM. Inhibition of Src family kinases by PP1 has been shown to: prevent a-thrombin-stimulated Akt phosphorylation, delay PAF-mediated STAT3 phosphorylation, block Zn2+-induced Ras activation, block adhesion-dependent tyrosine phosphorylation of p105HEF1 5, and inhibit HLA-DR-induced tyrosine phosphorylation without affecting the activation of ERK1/2.
Formula:
C₁₆H₁₉N₅ MW: 281,4 g/mol |
MDL Number:
MFCD01076570 CAS Number: 172889-26-8 |
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