Ac-Cys(farnesyl)-OH ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Methyltransferase inhibitor
Members of the Ras superfamily of G proteins, gamma-subunits of heterotrimeric G proteins and the alpha-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the gamma-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry.
Formula:
C₂₀H₃₃NO₃S MW: 367,55 g/mol |
MDL Number:
MFCD00871540 CAS Number: 135304-07-3 |
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