N-Hexanoyl-D-erythro-sphingosine ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES AG
Synonyms:
C6 ceramide, Caproyl ceramide, N-((2S,3R,E)-1,3-Dihydroxyoctadec-4-en-2-yl)hexanamide
A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G0/G1 transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.
- Cell-permeable ceramide analog
White waxy solid.
Soluble in 100% ethanol (>25mg/ml) and DMSO (>50mg/ml).
Formula:
C₂₄H₄₇NO₃ MW: 397,644 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD00870174 CAS Number: 124753-97-5 |
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