MDL-28170

Supplier: ENZO LIFE SCIENCES

BML-PI130-0050 BML-PI130-0010 BMLPI1300010 BMLPI1300050
ALEXBML-PI130-0050EA 334 GBP
ALEXBML-PI130-0050 ALEXBML-PI130-0010 ENZOBMLPI1300010 ENZOBMLPI1300050
MDL-28170
Proteins and Peptides

A potent and selective cell permeable calpain inhibitor. Inhibits oxidative damage-induced apoptosis in PC12 cells and capsaicin-induced apoptosis in dorsal root ganglion neurons. It protects against anoxia in rat optic nerves and reduces neuronal damage in an animal model of global cerebral ischemia(50 mg/kg). In isolated hippocampal pyramidal neurons, it inhibits Ca²⁺-induced suppression of neurite outgrowth (complete inhibition at 20 µM). Calpain I Ki = 8 nM; Cathepsin B Ki = 24 nM in isolated enzyme assays. IC50 = 0,3 µM in intact cell assay.


  • Calpain and cathepsin inhibitor


Soluble in DMSO (200 mM).

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