Merck to Merck Millipore for the pharmaceutical industry

Lichrosolv® and EMSURE® solvents, acids, salts, Chromolith® chromatography columns and MAS-100 NT® Air samplers for your application in the pharmaceutical industry.

In this page, you will find Analytical Application Notes for Pharma industry to help you find the right tool in a wide range of techniques.

These Merck application notes contain all the relevant technical information you need to perform and succeed in your method. 
All these application notes can be easily downloaded as a pdf file.

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R&D

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The new Chromolith® WP300 columns are designed specifically for bio applications. Wide pore (WP) 300A monolithic silica columns are made of a single continuous bed- rod of high purity porous silica that is then bonded with C18, C8 and C4. Protein benefits of preparative columns:

  • High biorecovery and special selectivities for biomolecules
  • High speed separation possible
  • Substantially longer column lifetime
  • High resistance to column blockage
  • Cost savings from higher sample throughput and column durability

See Chromolith® WP300 products

Quality control

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EMSURE® acids, salts and solvents offer you:

  • Accuracy and reliability – every time
  • Convenience and safety
  • Regulatory compliance (ISO 6353, ACS, Reag. Ph. Eur.)

They are tested for up to 70 parameters in Merck’s stringent quality control lab in Darmstadt, Germany.
Discover, for example, product specifications of acetic acid, Reag. Ph. Eur. analytical reagent

1.00063.1000.

 

The specifications include over 50 parameters, far more than the amount of parameters
required for Ph. Eur.



See EMSURE® products

Environment
 

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See Spectroquant® spectrophotometers

Production
 

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General

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Merck Application Notes for Pharmaceuticals companies

Chromatography

Impact of mobile phase additives on LC-MS sensitivity Demonstrated using spice cannabinoids

Comparison of Supel™ BioSPME 96-Pin Device to Rapid Equilibrium Dialysis Technique for Determination of Plasma Protein Binding

HPLC Analysis of Dehydroascorbic Acid and Ascorbic Acid (Vitamin_C) on SeQuant ZIC HILIC

HPLC Analysis of Pain Relievers on Ascentis Express

HPLC Tips and Tricks-Mobile Phase Preparation

HPTLC Application for Passiflora incarnata

Identification, Assay and Organic Impuritiy Profiling Methods for Aripiprazole following the USP Monograph

LC MS Analysis of Sorbitol and Mannitol on SeQuant ZIC HILIC

Peptide Mapping Analysis Workflow for Adalimumab

Sample Preparation of Serum Prior to Determination of Free Testosterone

TLC Identification Test for Dextromethorphan following European Pharmacopeia Monograph on Silica

UHPLC-MS Analysis of Released N-Glycans from Human IgG on a Supel™ Carbon LC Column

UHPLC-MS Bottom-Up Analysis of Trastuzumab on a BIOshell™A160 Peptide C18 Column

Workflow for the Analysis of Polysorbate 80 in Erbitux® Formulation

CHROM HPLC Analysis of Letrozole and its impurities

Determination of Ephedrine HCl and Pseudoephedrine HCl

Determination of Ruthin in Anti-Aging Skin Cream Formulation Using Chromolit

Fast Analysis of Monoclonal Antibodies Using Silica Monoliths Designed for Bioanalysis

Environment

SQ ultrasensitive determination of silicate in process and boiler water clean.pdf

Karl Fisher

Water in Antibiotics

Water in Lyophilisates

Water in Acetyl salicylic acid

Microbiology

EN 17141 Impact on ISO 14698 Validation MAS-100 Air Samplers

Media Fill Testing Cold Filterability Study.

Active air sampling with Tryptic soy agar

Air outlet particle filter for viable air sampler MAS-100 NT

Measure autoclave sterilization effectiveness