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Image Unavailable-EDVO269

Experimentation kits, introduction to ELISA reactions

Description: Students learn the basic principles of the Enzyme-linked Immunosorbent Assay (ELISA) using this precise and sensitive antibody-based detection kit.
Catalog Number: EDVO269
UOM: 1 * 1 items
Supplier: EDVOTEK
Image Unavailable-BOSSBS-13390R-CY7

Anti-GLUD2 Rabbit Polyclonal Antibody (Cy7®)

Description: GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.
Catalog Number: BOSSBS-13390R-CY7
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-BINH1002727

Analogue oscilloscopes

Description: Educational Materials, Electricity/Magnetism, Application: Physics, Analogue oscilloscope, 30 MHz, microprocessor controlled
Catalog Number: BINH1002727
UOM: 1 * 1 items
Supplier: 3B Scientific
Image Unavailable-BOSSBS-11528R-A680

Anti-GALR3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: GALR3 a 368 and 370 amino acid protein in human and rat, respectively, belongs to a family of G protein-coupled receptors that bind the neuropeptide galanin, which is distributed throughout the central and peripheral nervous system, the pituitary gland, the gastrointestinal tract and in the endocrine and exocrine pancreas. GALR3 mRNA is widely distributed, but expressed at low abundance. In human, GALR3 mRNA is highly expressed in the hypothalamus, pituitary and testis, and is expressed to a lesser extent in adrenal gland and pancreas. Rat and human GALR3 co-express with potassium channel subunits GIRK1 and GIRK4. Like GALR1, GALR3 Signalling pathways lead to the inhibition of adenylate cyclase and to the activation of potassium channels, which are linked to the regulation of neurotransmitter release. Binding of galanin to galanin receptors results in increased feeding, impaired learning, enhanced opiate analgesia and decreased opiate place preference.
Catalog Number: BOSSBS-11528R-A680
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-EDVO270

Experimentation kits, antigen-antibody interaction: the ouchterlony procedure

Description: This experiment introduces students to the principles of antigen-antibody interactions by using the Ouchterlony procedure. Antibodies and antigens form complexes that precipitate, making it possible to assay antibody-antigen systems. The binding interaction results in the formation of a white precipitate after diffusion in agarose.
Catalog Number: EDVO270
UOM: 1 * 1 items
Supplier: EDVOTEK
Image Unavailable-ENZOADISPA805D

Anti-HSP60 Rabbit Polyclonal Antibody

Description: The Hsp60 of Heliothis viescens belongs to a highly conserved family of molecular chaperones from several species, including plant Hsp60 (known as Rubisco binding protein), GroEL, the E.coli Hsp60, and 65 kDa major antigen of mycobacteria. In eukaryotes, Hsp60 is localized in the mitochondrial matrix, and in plants Hsp60 is localized in the chloroplast. Mitochondria, chloroplasts and bacteria share a common ancestry (>1 billion years), and this coupled with the high degree of homology between the divergent Hsp60s suggests that these proteins perform a primitive but vital function similar to all the different species. The common characteristics shared by the Hsp60s from the divergent species include high abundance; induction with environmental stress such as heat shock; homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP; ATPase activity; and a role in folding and assembly of oligomeric protein structures. Studies support these similarities, showing expression of the single-ring human mitochondrial homolog Hsp60 with its co-chaperonin Hsp10, in a E. coli strain engineered so that the groE operon remained under strict regulatory control. The findings demonstrate that expression of Hsp60-Hsp10 enabled successful performance of all essential in vivo functions of GroEL and its co-chaperonin, GroES. Consistent with their functions as chaperones, Hsp60 and Hsp10 may act as docking molecules with a passive role in the maturation of caspase processing. Data incidates that recombinant Hsp60 and Hsp10 accelerate the activation of procaspase-3 by cytochrome c and dATP in an ATP-dependent manner. Hsps are intracellular proteins thought to serve protective functions against infection and cellular stress; however, several studies reveal a possible link between members of the Hsp60 and a number of autoimmune diseases, atherosclerosis, and chlamydial disease.
Catalog Number: ENZOADISPA805D
UOM: 1 * 50 µG
Supplier: ENZO LIFE SCIENCES
Product Image-EDVO275

Experimentation kits, simulation of HIV detection by western blot (agarose-based)

Description: The second assay used to confirm a positive HIV ELISA result is the Western blot. Using this kit, students separate protein samples from hypothetical patients on agarose gels. The proteins are then transferred to a membrane and simulated HIV proteins are detected.
Catalog Number: EDVO275
UOM: 1 * 1 items
Supplier: EDVOTEK
Product Image-DIDAPOD013210

He-Ne laser

Description: High quality professional gas laser, Class II
Catalog Number: DIDAPOD013210
UOM: 1 * 1 items
Supplier: DIDALAB
Product Image-763-0009

Kits: the case of the invisible bands, Ready-to-Load™

Description: Experiment using fluorescence and electrophoresis to solve the mystery of the invisible bands.
Catalog Number: 763-0009
UOM: 1 * 1 items
Supplier: EDVOTEK
Product Image-761-0268

Poster, alcohol dependence

Description: Educational Materials, Physiology and Health, Application: Biology, Poster - Alcohol Dependence, laminated
Catalog Number: 761-0268
UOM: 1 * 1 items
Supplier: 3B Scientific
Image Unavailable-EDVO616

ReadyPour™ Luria Broth (LB) agar with ampicillin

Description: Educational Materials, Microbiology, Application: Microbiology, ReadyPour™ LB agar with ampicillin
Catalog Number: EDVO616
UOM: 1 * 170 mL
Supplier: EDVOTEK
Product Image-BINH1014525

Tube holder S

Description: Tube holder to support all S series electron tubes for easy and safe operation. The five pin sockets for the tube are concealed inside the tube holder. A cathode protection switch is integrated into the tube holder, to protect the heated cathode from excessive voltage. The base plate has a slot for attaching the Helmholtz pair of coils S.
Catalog Number: BINH1014525
UOM: 1 * 1 items
Supplier: 3B Scientific
Product Image-DIDAPOD013136

Diode lasers, class II

Description: Educational Materials, Optics, Application: Physics, Diode laser, red, Class II
Catalog Number: DIDAPOD013136
UOM: 1 * 1 items
Supplier: DIDALAB
Image Unavailable-BOSSBS-0175R-FITC

Anti-TRKB Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Catalog Number: BOSSBS-0175R-FITC
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-0175R-A647

Anti-TRKB Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Description: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Catalog Number: BOSSBS-0175R-A647
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-EDVO123

Nucleic acid testing for COVID-19

Description: Hands-on simulation of molecular testing for COVID-19.
Catalog Number: EDVO123
UOM: 1 * 1 KIT
Supplier: EDVOTEK
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