You Searched For: ENZO LIFE SCIENCES

Supplier: ENZO LIFE SCIENCES

Description: Host: Hamster, Isotype: IgG1

Catalog Number: (ENZOALX804162C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgM

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804240BC100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804327C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: Synuclein was originally identified in Torpedo californica as a small neuroprotein that localized to the nuclear envelope of neurons and to presynaptic nerve termini. The human homolog was initially termed NACP, a precursor protein to NAC (Non-Ab Component), because of its prevalence in amyloid plaques in Alzheimer’s patients. Later, NACP was recognized as being alpha-Synuclein (alpha-SYN), a 14kDa protein, belonging to the synuclein family of phosphoproteins that also includes: betalpha-SYNuclein, gammalpha-SYNuclein, and synoretin.
alpha-SYN is recognized as a key component in the development and diagnosis of neurodegenerative synucleinopathic diseases (NSDs), such as Alzheimer’s and Parkinson’s disease. In the past five years, several genetic and post-translational modifications to alpha-SYN have been elucidated that have been linked to its collaboration in the formation of the classical Lewy bodies (LBs) or Lewy neurites that are associated with neurodegeneration. A study that shed more light on the neurogenesis of autorecessive synucleinopathies (ARSs) was the finding that alpha-SYN accumulation can occur due to mutations in the E3 ubiquitin ligase.
ARSs only account for a small percentage of NSD. Thus the illustration that alpha-SYN has a high susceptibility to tyrosine nitration may be the key component in understanding the formation of LBs. Due to the chemical structure of alpha-SYN, tyrosine nitration readily leads to the formation of oligomers via covalent O,O’-dityrosine bonds (cross-linking). Nitrosylated, wild-type, alpha-SYN products thus form SDS-insoluble, heat-stable aggregates in vitro that may account for alpha-SYN inclusions in all forms of NSDs.

Catalog Number: (ENZOALX804155C100)

Supplier: ENZO LIFE SCIENCES

Description: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNF-R1 and Fas, two prototype members in the death receptor family. A member in the RIP kinase family was identified and designated RIP3. RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues. Meanwhile RIP4 has been identified and initially characterized. These data suggest that RIP4 is involved in NF-κB and JNK signalling and that caspase-dependent processing of RIP4 may negatively regulate NF-κB-dependent pro-survival or pro-inflammatory signals.

UOM: 1 * 100 µG

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Supplier: ENZO LIFE SCIENCES

Description: Mycotoxin.

Catalog Number: (ENZOALX6301260200)

Supplier: ENZO LIFE SCIENCES

Description: From herpes simplex virus type 1. Inactivated by 0.1% Triton X-100.

UOM: 1 * 200 µl

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Catalog Number: (ENZOALX6301210100)

Supplier: ENZO LIFE SCIENCES

Description: From adenovirus type 40. Inactivated by 2 hours at 54°C.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804868C100)

Supplier: ENZO LIFE SCIENCES

Description: Chemerin (tazarotene-induced gene 2; TIG2) is a chemotactic agent that was identified as the ligand for the orphan G protein-coupled receptor ChemR23. Chemerin has been shown to be expressed abundantly in adipose tissue and to function as a adipokine. Chemerin potentiates insulin-stimulated glucose uptake and regulates adipogenesis and adipocyte metabolism.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804839C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804800C100)

Supplier: ENZO LIFE SCIENCES

Description: Host: Rat, Isotype: IgG2a

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX804806BC100)

Supplier: ENZO LIFE SCIENCES

Description: The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses.

UOM: 1 * 100 µG

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Catalog Number: (ENZOALX550409M010)

Supplier: ENZO LIFE SCIENCES

Description: Anti-inflammatory and anti-angiogenic

UOM: 1 * 10 mg

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Catalog Number: (ENZOALX581201L002)

Supplier: ENZO LIFE SCIENCES

Description: Isolated from Salmonella minnesota R595 (Re mutant). Prepared by mild acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method), converted to the uniform salt form and dissolved in sterile pyrogen-free double distilled water.

UOM: 1 * 2 mL

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Supplier: ENZO LIFE SCIENCES

Description: TLR4 activator.