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Image Unavailable-BOSSBS-3425R-A350

Anti-SMAD3 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-3425R-A350)
Supplier: Bioss
Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
UOM: 1 * 100 µl
Product Image-OXOIAG0031A

Accessories for Anaerobic Systems, Oxoid

Supplier: THERMO FISHER DIAGNOSTICS
Description: Where an AnaeroGen sachet is placed in a sealed jar, the atmospheric oxygen in the jar is rapidly absorbed with the simultaneous generation of carbon dioxide. This novel method differs from others commonly used in that the reaction proceeds with no evolution of hydrogen, and therefore, does not require a catalyst. Furthermore, water is not required to activate the reaction. When used as directed, the AnaeroGen sachet will reduce the oxygen level in the jar to below 1% within 30 minutes. The resulting carbon dioxide level will be between 9% and 13%.
CampyGen Compact for 1 or 2 Petri dishes, is a simple system for generating microaerobic conditions. The system consists of a plastic pouch and sealing clip and a paper gas generating sachet. The paper sachet contains ascorbic acid which reacts on contact with air to produce the microaerobic conditions for the growth of microaerophilic organisms.

Product Image-216-3248

Grating, White

Catalog Number: (216-3248)
Supplier: MULTIROIR
Description: <p><span style="color:black">Durable HDPE grating designed for laboratories. Its open-grid design ensures liquid drainage, minimizing slip risks. Resistant to chemicals and easy to disinfect, it supports strict hygiene standards. Quick to assemble with a clipping system, it’s ideal for safe, clean, and efficient lab environments.</span></p>
UOM: 1 * 1 items

New Product


Image Unavailable-BOSSBS-4286R-A680

Anti-VAV3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-4286R-A680)
Supplier: Bioss
Description: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organisation and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4286R-CY3

Anti-VAV3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-4286R-CY3)
Supplier: Bioss
Description: Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3-mediated adhesion. Does not affect integrin beta-1-mediated adhesion.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5490R-HRP

Anti-MST1R Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-5490R-HRP)
Supplier: Bioss
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10118R-CY5

Anti-MST1R Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-10118R-CY5)
Supplier: Bioss
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
UOM: 1 * 100 µl
Product Image-312-0106

Bag closures, WeLoc®

Supplier: WELOC
Description: These sealing clips are perfect for use in the demanding pharmaceutical and laboratory environment because they are made from high quality Polyamide 6.6 material from DuPont®. The clips help to maintain hygiene standards, securing opened bags of raw ingredients and materials, such as powders and fluids.

Product Image-BSENC-1510-500

Anti-Leptin Chicken Polyclonal Antibody

Catalog Number: (BSENC-1510-500)
Supplier: Biosensis
Description: Leptin is secreted by white adipocytes and functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. Leptin also has several endocrine functions and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing (Ref: Entrez Gene).
UOM: 1 * 500 µl
Product Image-BSENC-1515-500

Anti-Leptin, Rat Chicken Polyclonal Antibody

Catalog Number: (BSENC-1515-500)
Supplier: Biosensis
Description: Leptin is secreted by white adipocytes and functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. Leptin also has several endocrine functions and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing (Ref: Entrez Gene) .
UOM: 1 * 500 µl
Image Unavailable-BOSSBS-2101R-CY7

Anti-CD248 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-2101R-CY7)
Supplier: Bioss
Description: The transmembrane glycoprotein Tumor endothelial marker 1 (TEM1) is highly expressed in tumor endothelial cells however it is barely detectable on normal endothelial cells. It is believed to play a role in tumor angiogenesis. It is expressed in stromal fibroblasts, metastatic hepatic lesions and during angiogenesis of corpus luteum formation and wound healing. TEM1 is being investigated as a potential target for cancer treatment.
UOM: 1 * 100 µl
Product Image-PLUM5551

Wound cleansers, QuickClean

Catalog Number: (PLUM5551)
Supplier: Plum Safety
Description: These moist wipes are ideal for the quick and easy cleansing of minor wounds and cuts.
UOM: 1 * 40 items
Product Image-HEID571-34300-00

Rotary evaporators, Hei-VAP Core

Supplier: Heidolph Instruments GmbH & Co.KG
Description: These evaporators are equipped with proven smart details such as Easy-Clip, patented clamping sleeve, lift stop to limit immersion depth and universal 5 L heating bath.

Product Image-SOLUL-7209-100

TriLink® CleanCap® EPO mRNA (5moU)

Supplier: TriLink BioTechnologies
Description: EPO mRNA encodes the human erythropoietin (EPO) protein, a hormone that controls erythropoiesis, or red blood cell production. EPO also plays a role in wound healing and the brain’s response to neural injury. Kariko <em>et al.</em> showed that transfection of EPO mRNA <em>in vivo</em> resulted in significant increases of both reticulocyte counts and hematocrits.

New Product

Image Unavailable-BNUB0813-100

Anti-CD74 Mouse Monoclonal Antibody (Purified) [clone: CLIP/813]

Supplier: Biotium
Description: This antibody recognizes a protein of ~35 kDa, identified as CD74. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma ( ).

Image Unavailable-BNC940813-500

Anti-CD74 Mouse Monoclonal Antibody (CF594) [clone: CLIP/813]

Supplier: Biotium
Description: This antibody recognizes a protein of ~35 kDa, identified as CD74. It is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma ( ).

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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