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Catalog Number: (BOSSBS-12355R-CY3)
Supplier: Bioss
Description: Glut4 is a twelve pass transmembrane protein (12TM) whose carboxy-terminus may dictate its cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity. TUG (ASPL in humans) regulates the trafficking of glucose via Glut4. Full-length TUG forms a complex with Glut4 and in 3T3-L1 adipocytes and this complex is present in unstimulated cells and is disassembled by insulin. TUG acts by trapping endocytosed Glut4 and tethering it intracellularly. Insulin mobilizes this pool of retained Glut4 by releasing the tether.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-4284R-CY7)
Supplier: Bioss
Description: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-4284R-CY5)
Supplier: Bioss
Description: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
UOM: 1 * 100 µl


Catalog Number: (12956.22)
Supplier: Thermo Fisher Scientific
Description: Cobalt ≥99.9% (metals basis), lumps typ. 1.5 cm cubes low oxygen, vacuum remelted
UOM: 1 * 100 g

Supplier: Merck
Description: Ideal for sterilising tissue culture media, buffers, or other aqueous solutions. The no tip, tapered receiver flask and compact profile of the Stericup® design improve stability and make gripping the receiver easier.

Catalog Number: (BOSSBS-5517R-CY5.5)
Supplier: Bioss
Description: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NFKB interaction with other transcription factors, such as STAT, AP1 (JUN), and NFAT.
UOM: 1 * 100 µl


Supplier: Thermo Fisher Scientific
Description: O-Ring refresher kit (5 o-rings, 3 vacuum grease packets), for use with F37L-8×100, For: Fiberlite™ rotors

New Product

Supplier: SP Industries
Description: Borosilicate glass

Supplier: Merck
Description: <p>Work with ease and filter with confidence with Stericup® and Steritop® filtration systems. The Stericup® E and Steritop® E sterile filters have been designed to reduce plastic and packaging.</p>

Catalog Number: (BOHLB293-02)
Supplier: Bohlender
Description: Made of PTFE.
UOM: 1 * 1 items


Catalog Number: (516-1226)
Supplier: Cytiva (Formerly Pall Lab)
Description: Filter holder, Vacuum port adaptor, SolVac®
UOM: 1 * 5 items

New Product


Supplier: Sartorius
Description: These vacuum filter holders feature a glass cylinder, PP base and sealing plug with anodised aluminum closing cap.

Supplier: Thermo Fisher Scientific
Description: Bottle top filter, Nalgene®, Kit of 4 bottle-top gaskets (OD 42,4 mm)

Environmentally Preferable

Catalog Number: (ANTIA73803-96)
Supplier: ANTIBODIES.COM
Description: Porcine TRAP/CD40L ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of porcine TRAP/CD40L in serum, plasma, tissue homogenates, and other biological fluids.
UOM: 1 * 96 Tests

New Product


Supplier: Thermo Fisher Scientific
Description: Cellulose nitrate membrane, upper: PP, lower: PS. Ready to use for microbial analysis, water quality or environmental testing.
Supplier: Merck
Description: Ideal for sterilising tissue culture media, buffers, or other aqueous solutions. The no tip, tapered receiver flask and compact profile of the Stericup® design improve stability and make gripping the receiver easier.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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