You Searched For: Tyrphostin+AG+490


10,591  results were found

SearchResultCount:"10591"

Sort Results

List View Easy View

Rate These Search Results

Supplier: ENZO LIFE SCIENCES AG
Description: AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

New Product

Catalog Number: (ENZOALX270141M025)
Supplier: ENZO LIFE SCIENCES AG
Description: Tyrphostin AG 527 ≥98% (by HPLC)
UOM: 1 * 25 mg

New Product


All-day power. Every day durability

Work quickly with the compact, powerful M510 and M611 Label Printers, delivering high-volume, high-quality labels via Bluetooth or Wi-Fi

Learn more

Meet the M510 & M611 Label printers

Supplier: ENZO LIFE SCIENCES AG
Description: Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

New Product

Supplier: Apollo Scientific
Description: MAPK/ERK Signalling Pathway

Supplier: Apollo Scientific
Description: Tyrphostin 1 95%

Supplier: ENZO LIFE SCIENCES AG
Description: Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

New Product

Catalog Number: (ENZOBMLEI1890005)
Supplier: ENZO LIFE SCIENCES AG
Description: A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.
UOM: 1 * 5 mg

New Product


Supplier: Apollo Scientific
Description: Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 uM). Eur. J. Biochem. 225: 1047-1053 (1994).

Supplier: ENZO LIFE SCIENCES AG
Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

New Product

Catalog Number: (ENZOALX270035M005)
Supplier: ENZO LIFE SCIENCES AG
Description: Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
UOM: 1 * 5 mg

New Product


Supplier: ENZO LIFE SCIENCES AG
Description: EGFR inhibitor

New Product

Supplier: ENZO LIFE SCIENCES AG
Description: A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

New Product

Supplier: ENZO LIFE SCIENCES AG
Description: An inactive tyrphostin, which may be used as a negative control.

New Product

Catalog Number: (ENZOBMLEI1870005)
Supplier: ENZO LIFE SCIENCES AG
Description: A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).
UOM: 1 * 5 mg

New Product


Supplier: ENZO LIFE SCIENCES AG
Description: Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

New Product

Supplier: ENZO LIFE SCIENCES AG
Description: NGF receptor inhibitor

New Product

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
1 - 16 of 10,591
no targeter for Bottom