Description: The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralisation of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.

Catalog Number: BOSSBS-4292R-A680

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: The 61D3 antibody is specific for human CD14, a 53-55 kDa GPI-anchored glycoprotein. CD14 is highly expressed on monocytes and to a lesser extent on interfollicular macrophages, and some dendritic cells. Together with LPS-Binding Protein (LBP), CD14 binds to and mediates the innate immune response to bacterial lipopolysaccharide (LPS).

Catalog Number: 75-0149-T025

UOM: 1 * 25 Tests

Supplier: Tonbo Biosciences

Sale

Description: The 61D3 antibody is specific for human CD14, a 53-55 kDa GPI-anchored glycoprotein. CD14 is highly expressed on monocytes and to a lesser extent on interfollicular macrophages, and some dendritic cells. Together with LPS-Binding Protein (LBP), CD14 binds to and mediates the innate immune response to bacterial lipopolysaccharide (LPS).

Catalog Number: 35-0149-T100

UOM: 1 * 100 Tests

Supplier: Tonbo Biosciences

Sale

Description: CD14 is a cell surface glycoprotein that is preferentially expressed on monocytes/macrophages. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a pattern recognition receptor that binds lipopolysaccharides (LPS) and a variety of ligands derived from different microbial sources. The binding of CD14 with LPS is catalyzed by LPS binding protein (LBP). Toll like receptors have also been implicated in the transduction of CD14-LPS signals. Soluble CD14 can be released from the cell surface by phosphatidyinositolspecific phospholipase C and has been detected in serum and body fluids. High concentrations of soluble CD14 have been shown to inhibit LPS mediated responses. However, soluble CD14 can also potentiate LPS response in cells that do not express cell surface CD14.

Catalog Number: PRSI91-288

UOM: 1 * 50 µG

Supplier: ProSci Inc.

Sale

Description: The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.

Catalog Number: BOSSBS-4292R-A555

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.

Catalog Number: BOSSBS-4292R-A350

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: The antimicrobial protein Bactericidal Permeability Increasing protein (BPI) is a 55 kDa protein found in the primary granules of polymorhonuclear leukocytes (PMN). The cytotoxicity action of BPI is limited to gram negative bacteria, reflecting the high affinity of BPI for bacterial LPS. Binding of BPI to live bacteria via LPS causes anti-infective activites: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils.

Catalog Number: BOSSBS-4292R-A488

UOM: 1 * 100 µl

Supplier: Bioss

Sale

Description: Mouse monoclonal antibody raised against lipopolysaccharides (LPS) from Salmonella typhimurium.

Catalog Number: ABNOMAB0626

UOM: 1 * 200 µG

Supplier: Abnova

Sale

Description: LPS FROM ESCHERICHIA COLI O111:B4 1 * 10 mg

Catalog Number: CAYM19661-10

UOM: 1 * 10 mg

Supplier: Cayman Chemical

Sale

Description: LBP is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP).The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.

Catalog Number: PRSI29-596

UOM: 1 * 50 µG

Supplier: ProSci Inc.

Sale

Description: Lipopolysaccharide (LPS), also known as endotoxin, is the major component of the outer membrane of Gram-negative bacteria.

Catalog Number: AATB60006

UOM: 1 * 100 Tests

Supplier: AAT BIOQUEST

Sale

Description: Lipopolysaccharide (LPS), also known as endotoxin, is the major component of the outer membranes of Gram-negative bacteria.

Catalog Number: AATB60007

UOM: 1 * 100 Tests

Supplier: AAT BIOQUEST

Sale

Description: Lipopolysaccharide (LPS), also known as endotoxin, is the major component of the outer membranes of Gram-negative bacteria.

Catalog Number: AATB60009

UOM: 1 * 500 Tests

Supplier: AAT BIOQUEST

Sale

Description: SLA/LP converts O-phosphoseryl-tRNA (Sec) to selenocysteinyl-tRNA (Sec) required for selenoprotein biosynthesis.

Catalog Number: PRSI29-515

UOM: 1 * 50 µG

Supplier: ProSci Inc.

Sale

Description: Inhibitor of LPS-induced NF-+kappa B DNA binding activity and COX-2 catalytic activity 1 * 1 g

Catalog Number: ABCAAB146814-1

UOM: 1 * 1 g

Supplier: Abcam

Sale

Description: AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Catalog Number: ENZOBMLEI2630025

UOM: 1 * 25 mg

Supplier: ENZO LIFE SCIENCES

Sale