You Searched For: 6-Cyclobutoxypyridine-2-carboxylic+acid

Supplier: Avantor

Description: Column type: GC column, Avantor® Hichrom, GC column, Fused silica, Ø int.: 0,32 mm, Length: 10 m, Film thickness: 1,50 µm

Supplier: Avantor

Description: Column type: GC column, Avantor® Hichrom, GC column, Fused silica, Ø int.: 0,25 mm, Length: 50 m, Film thickness: 1,00 µm

Catalog Number: (PRSI55-168)

Supplier: ProSci Inc.

Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined.

UOM: 1 * 400 µl

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Supplier: HAMILTON BONADUZ

Description: Syringe, chromatography, GC, 1701 ASN, Volume: 10 µl, Type of tip: AS, Gauge: 23s, Pk: 6

Supplier: Thermo Fisher Scientific

Description: Syringe, chromatography, GC, Luer tip, gas tight, Volume: 2500 µl, Pk: 1

Catalog Number: (PRSI55-132)

Supplier: ProSci Inc.

Description: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

UOM: 1 * 400 µl

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Supplier: VWR Collection

Description: Micro syringe with fixed needle for high sensitivity GC analysis and ultra-minute volumes.

Supplier: Avantor

Description: Column type: GC column, Avantor® Hichrom, GC column, Fused silica, Ø int.: 0,32 mm, Length: 15 m, Film thickness: 0,10 µm

Supplier: HAMILTON BONADUZ

Description: Syringe, chromatography, Microliter™, HPLC/GC, 7101 KHCH, Volume: 1 µl, Gauge: 22, Length: 70 mm, Pk: 1

Catalog Number: (PRSI55-131)

Supplier: ProSci Inc.

Description: Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2Fbinding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells.

UOM: 1 * 400 µl

New Product Sale

Catalog Number: (PRSI56-109)

Supplier: ProSci Inc.

Description: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

UOM: 1 * 400 µl

New Product Sale

Supplier: Trajan Scientific and Medical

Description: Constructed from borosilicate glass, PTFE plunger tips and Kel-F® or PTFE Luer cones where applicable.

Supplier: Avantor

Description: Column type: GC column, Avantor® Hichrom, GC column, Fused silica, Ø int.: 0,18 mm, Length: 40 m, Film thickness: 0,10 µm

Supplier: Trajan Scientific and Medical

Description: Autosampler syringes for PerkinElmer AutoSystem.

Supplier: Merck

Description: These non-polar methyl silicone bonded poly(dimethyl siloxane) columns are used to separate the sample components according to boiling point.

Supplier: Trajan Scientific and Medical

Description: These are plunger-in-barrel syringes. Each plunger is individually fitted for each microsyringe for perfect sealing.