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Supplier: AAT BIOQUEST

Description: Covidyte™ EN450 is a peptide substrate containing 14 amino acid sequence (KTSAVLQSGFRKME) that can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) and Edans (donor) on the N-and C-terminals respectively where the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When the peptide is hydrolysed by coronavirus proteases, the Edans fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by Dabcyl. The activity of coronavirus proteases can be effectively monitored by the fluorescence intensity of Edans. Covidyte™ EN450 is a convenient tool for screening inhibitors of coronavirus proteases.

Supplier: AAT BIOQUEST

Description: Covidyte™ ED450 is a peptide substrate containing 12 amino acid sequence (VNSTLQSGLRKM) that can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) and Edans (donor) on the C-and N-terminals respectively where the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When the peptide is hydrolyzed by coronavirus proteases, the Edans fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by Dabcyl. The activity of coronavirus proteases can be effectively monitored by the fluorescence intensity of Edans. Covidyte™ ED450 is a convenient tool for screening inhibitors of coronavirus proteases.

Supplier: AAT BIOQUEST

Description: Covipyte™ EN450 is a peptide substrate containing 9 amino acid sequence (RELNGGAPI) that can be cleaved by coronavirus PLpro. The dark-FRET peptide contains Edans (donor) and Dabcyl (quencher) on the N-and C-terminals respectively where the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When the peptide is hydrolysed by coronavirus proteases, the Edans fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by Dabcyl. The activity of coronavirus proteases can be effectively monitored by the fluorescence intensity of Edans. Covipyte™ EN450 is a convenient tool for screening and studying kinetics of PLpro inhibitors.

Supplier: Biotium

Description: This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60% of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (beta-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

Catalog Number: (BNUM1006-50)

Supplier: Biotium

Description: This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60% of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (beta-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

UOM: 1 * 50 µl

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Supplier: BIOPREMIER

Description: Food safe kits provide a simple, reliable, and rapid procedure for detecting the presence of a specific pathogenic bacteria. The assay is based on 5’ nuclease Real-Time PCR reactions to amplify a unique genomic sequence in the target microorganism. PCR is a method used to amplify a specific DNA sequence which is typically amplified in a reaction containing a thermostable DNA polymerase, nucleotides, and primers complementary to the target sequence. When this solution is heated, the DNA molecule denatures, separating into two strands. As the solution cools, the primers anneal to the target sequences in the separated DNA strands and the DNA polymerase synthesises a new strand by extending the primers with nucleotides, creating a copy of the DNA sequence (amplicons). When repeated, this cycle of denaturing, annealing, and extending exponentially increases the number of target amplicons. In Real-Time PCR, specific fluorescent probes are used to detect the amplified DNA by hybridising with amplicons. These probes are linked to a fluorophore on one end and a quencher that suppresses fluorescence on the other. If the target sequence is present during the PCR, amplification occurs and the probe is degraded, resulting in fluorescence increase. Fluorescence is measured by a detector and the associated software plots the fluorescence intensity versus number of cycles, allowing the determination of the presence or absence of the target organism.

Catalog Number: (MSPPAX09-07512-1G)

Supplier: MARKET SOURCE PART PROCESS

Description: 2ʹ-O-methyl MeU phosphoramidite 1 * 1 g

UOM: 1 * 1 g

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Catalog Number: (MSPPAX09-02338-1G)

Supplier: MARKET SOURCE PART PROCESS

Description: 2ʹ,3ʹ-switch MOE A phosphoramidite 1 * 1 g

UOM: 1 * 1 g

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Catalog Number: (MSPPGL102659)

Supplier: MARKET SOURCE PART PROCESS

Description: 3’-O-MOE-A(Bz)-2’-CED-phosphoramidite N6-Bz-5’-O-DMTr-3’-O-(2-methoxyethyl)adenosine-2’- CED-phosphoramidite 1 * 2 g

UOM: 1 * 2 g

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Catalog Number: (MSPPAX09-15628-2G)

Supplier: MARKET SOURCE PART PROCESS

Description: 2ʹ,3ʹ-switch MOE A phosphoramidite 1 * 2 g

UOM: 1 * 2 g

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Catalog Number: (MSPP153631-20-0)

Supplier: MARKET SOURCE PART PROCESS

Description: 5-O-DMT-2-O-methyl-5-met hyluridine 3-CE phosphoramidite 1 * 1 g

UOM: 1 * 1 g

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Catalog Number: (MSPPAX09-18130-1G)

Supplier: MARKET SOURCE PART PROCESS

Description: 3ʹ,5ʹ-switch dG phosphoramidite 1 * 1 g

UOM: 1 * 1 g

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Catalog Number: (MSPPGL103850-2G)

Supplier: MARKET SOURCE PART PROCESS

Description: 3’,5’-switch MOE A phosphoramidite, Rev 2’-O-MOE-A(Bz)-5’-amidite N6-Benzoyl-3’-O-(4,4’- dimethoxytrityl)-2’-O-(2-methoxyethyl)aden osine-5’-CED phosphoramidite 1 * 2 g

UOM: 1 * 2 g

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Catalog Number: (23014.)

Supplier: Biotium

Description: TrueBlack® Plus Lipofuscin Autofluorescence Quencher, 40X in DMSO 1 * 500 µl

UOM: 1 * 500 µl

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Catalog Number: (23014-T)

Supplier: Biotium

Description: TrueBlack® Plus Lipofuscin Autofluorescence Quencher, 40X in DMSO 1 * 50 µl

UOM: 1 * 50 µl

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Catalog Number: (MSPPGL103836-1G)

Supplier: MARKET SOURCE PART PROCESS

Description: 3’,5’-switch MOE MeU phosphoramidite, Rev 2’-O-MOE-5MeU-5’-amidite 3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridi ne-5’-CED phosphoramidite 1 * 1 g

UOM: 1 * 1 g

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 This is a MarketSource item. Additional charges may apply