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Description: Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases including atopic dermatitis, psoriasis, and Netherton syndrome. Studies have shown that Kallikrein 5 is a potential physiological activator for Kallikrein 7. The proform of Kallikrein 7 can be activated by thermolysin.
Catalog Number: PRSI91-335
UOM: 1 * 50 µG
Supplier: ProSci Inc.


Description: CP-31398 restores mutant p53 tumor suppressor function in vitro without affecting p53 homologs p63 and p73, and in vivo inhibiting UVB-induced skin carcinogenesis in mice. Stabilization of p53 inhibits ubiquitination without altering phosphorylation at Ser12 or Ser20 or MDM2 binding. Administration of this or similar compounds has the potential to enhance cytotoxic chemotherapy.
Catalog Number: ENZOBMLGR3600050
UOM: 1 * 50 mg
Supplier: ENZO LIFE SCIENCES


Description: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
Catalog Number: BOSSBS-1428R-A350
UOM: 1 * 100 µl
Supplier: Bioss


Description: Diving safety shoes feature a water-resistant, full grain leather upper, SmellStop anti-odour and anti-bacterial lining, Fresh’n Flex midsole, SlimCap protective toe cap, and anti-fatigue AirTech + TPU-Skin sole.
Catalog Number: PRTWB0605BKG36
UOM: 1 * 1 PAIR
Supplier: Portwest


Description: Antistatic safety shoe made from hydrophobised nubuck leather, mesh inserts and reflective materials, skin-friendly textile lining, a full, padded bellows tongue and collar, and a dual-density rubber/PU jo_MAX sole (3,0 mm profile, oil, fuel and chemical resistant, temperature resistant from approx. −20 and +200 °C).
Catalog Number: ELTN12771/36
UOM: 1 * 1 PAIR
Supplier: ELTEN

Environmentally Preferable


Description: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 3 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Catalog Number: BOSSBS-0527R-CY7
UOM: 1 * 100 µl
Supplier: Bioss


Description: This cover protects and relieves the pain caused by minor burns. The cushion is a cool water-based hydrogel that covers the nerve endings of the skin, helping to relieve pain. It also creates a moist environment that prevents scabs from forming and promotes faster healing.
Catalog Number: 118-0384
UOM: 1 * 10 items
Supplier: ORKLA CARE


Description: Safety shoes made from hydrophobised, quick drying, tear resistant textile upper combined with reflective materials, skin friendly textile lining, a full padded bellows tongue and collar padding plus a dual-density PU/PU (New Basic) sole (oil, fuel and abrasion resistant, heat resistant up to approx. 130 °C).
Catalog Number: ELTN12941/41
UOM: 1 * 1 PAIR
Supplier: ELTEN

Environmentally Preferable


Description: 100% metal-free, extremely lightweight safety shoes made from cowhide leather, reflective materials, skin friendly textile lining, a full padded bellows tongue and collar padding plus a dual-density PU/PU jo_Basic sole (oil, fuel and abrasion resistant, also heat resistant up to approx. 130 °C).
Catalog Number: ELTN12111/44
UOM: 1 * 1 PAIR
Supplier: ELTEN

Environmentally Preferable


Description: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.Tissue specificity:Predominantly expressed in skin.Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
Catalog Number: BOSSBS-7856R-CY3
UOM: 1 * 100 µl
Supplier: Bioss


Description: Integrins are a major class of cell adhesion molecules that mediate cell matrix interactions. They are composed of an alpha and a beta subunit. Beta 1 heterodimers are widely expressed and control various developmental processes, including neurogenesis, chondrogenesis, myoblast fusion, and skin and hair follicle morphogenesis.
Catalog Number: PRSI48-408
UOM: 1 * 50 µG
Supplier: ProSci Inc.


Description: Antistatic safety ankle boot made from hydrophobised nubuck leather, mesh inserts and reflective materials, skin-friendly textile lining, a full, padded bellows tongue and collar, and a dual-density rubber/PU jo_MAX sole (3,0 mm profile, oil, fuel and chemical resistant, temperature resistant from approx. -20 and +200 °C).
Catalog Number: ELTN16731/41
UOM: 1 * 1 PAIR
Supplier: ELTEN

Environmentally Preferable


Description: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.Tissue specificity:Predominantly expressed in skin.Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
Catalog Number: BOSSBS-7856R-A488
UOM: 1 * 100 µl
Supplier: Bioss


Description: Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known.Tissue specificity:Predominantly expressed in skin.Involvement in diseaseDefects in ALOXE3 are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE). NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume.
Catalog Number: BOSSBS-7856R-HRP
UOM: 1 * 100 µl
Supplier: Bioss


Description: Antistatic safety shoe made from hydrophobised nubuck leather, mesh inserts and reflective materials, skin-friendly textile lining, a full, padded bellows tongue and collar, and a dual-density rubber/PU jo_MAX sole (3,0 mm profile, oil, fuel and chemical resistant, temperature resistant from approx. -20 and +200 °C).
Catalog Number: ELTN12731/45
UOM: 1 * 1 PAIR
Supplier: ELTEN

Environmentally Preferable


Description: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 3 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
Catalog Number: BOSSBS-0527R-A555
UOM: 1 * 100 µl
Supplier: Bioss


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