You Searched For: SMCC+(N-Succinimidyl+4-(N-Maleimidomethyl)cyclohexanecarboxylate)

Catalog Number: (BC20)

Supplier: G-Biosciences

Description: Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate Heterobifunctional Cross Linkers.

UOM: 1 * 100 mg

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Supplier: Apollo Scientific

Description: Primary amine and Sulphhydryl reactive, Enzyme antibody conjugation.

Catalog Number: (PIERA35394)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

UOM: 1 * 10 mg

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Catalog Number: (573114-100)

Supplier: Merck Millipore (Calbiochem‎)

Description: Heterobifunctional reagent useful for enzyme labeling of antibodies and antibody fragments. Cross-links both a sulfhydryl group and a free amine group. Useful for sequential conjugation to minimize polymerization.
Reacts with primary amines and sulfhydryl groups.

UOM: 1 * 100 mg

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Catalog Number: (PIER22360)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

UOM: 1 * 50 mg

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Supplier: AAT BIOQUEST INC

Description: SMCC is a non-cleavable and membrane permeable crosslinker with a spacer arm of 8.3 Å. It contains an amine-reactive succinimidyl ester (SE) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7 to 9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5 to 7.5 to form stable thioether bonds. The SE group of SMCC is reacted with lysine residues on the carrier protein, converting them to reactive maleimides. SMCC is a reagent that is widely used for generating stable maleimide-activated carrier proteins that can spontaneously react with sulfhydryls. Alternatively these relatively stable maleimide-activated intermediates may be lyophilized and stored for later conjugation to a hapten.

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Supplier: SIGMA-ALDRICH MICROSCOPY

Description: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt,powder (Sulfo-SMCC)

Supplier: Thermo Scientific

Description: Sulpho-SMCC (3-Sulpho-N-succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt) ≥97%

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Catalog Number: (BC23)

Supplier: G-Biosciences

Description: Ideal for enzyme-antibody crosslinking.

UOM: 1 * 100 mg

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Catalog Number: (APOSBICL207-100MG)

Supplier: Apollo Scientific

Description: Primary amine & Sulphhydryl reactiveEnzyme-antibody conjugation -Stable maleimide groupRef: Hushida, S. et al (1984) J.Applied Biochem. 56,56-63

UOM: 1 * 100 mg

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Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Premium Grade Sulfo-SMCC is our highest quality formulation of amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount.

Catalog Number: (PIERA39268)

Supplier: Thermo Fisher Scientific

Description: Thermo Scientific Pierce Sulfo-SMCC, No-Weigh Format is a water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 angstroms).

UOM: 1 * 20 mg

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Catalog Number: (786-082)

Supplier: G-Biosciences

Description: Ideal for enzyme-antibody crosslinking.

UOM: 1 * 8 items

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Catalog Number: (AATB4503)

Supplier: AAT BIOQUEST INC

Description: Compared to SMCC and sulfo-SMCC, SMCC Plus has enhanced water solubility and crosslinking efficiency.

UOM: 1 * 5 mg

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Catalog Number: (573115-50)

Supplier: Merck Millipore (Calbiochem‎)

Description: SMCC, Water-Soluble, a water-soluble derivative of SMCC.

UOM: 1 * 50 mg

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