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Image Unavailable-BOSSBS-13070R-A350

Anti-ENOSF1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-13070R-A350)
Supplier: Bioss
Description: The rTS gene codes for a naturally occurring antisense RNA to thymidylate synthase (TS) mRNA and two proteins (rTSalpha and rTSbeta (also known as ENOSF1)). The role of the major protein product of rTS, ENOSF1 has been linked to alterations in TS protein expression, but the precise function of ENOSF1 is unknown. Expression of rTS is associated with growth arrest in cell culture, but its overexpression has been noted in cells resistant to anticancer drugs such as 5-fluorouracil and methotrexate. Studies have shown that increased expression of ENOSF1 is associated with the decrease in TS protein expression due to production of novel, diffusible signal molecules.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13070R-FITC

Anti-ENOSF1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-13070R-FITC)
Supplier: Bioss
Description: The rTS gene codes for a naturally occurring antisense RNA to thymidylate synthase (TS) mRNA and two proteins (rTSalpha and rTSbeta (also known as ENOSF1)). The role of the major protein product of rTS, ENOSF1 has been linked to alterations in TS protein expression, but the precise function of ENOSF1 is unknown. Expression of rTS is associated with growth arrest in cell culture, but its overexpression has been noted in cells resistant to anticancer drugs such as 5-fluorouracil and methotrexate. Studies have shown that increased expression of ENOSF1 is associated with the decrease in TS protein expression due to production of novel, diffusible signal molecules.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11324R-A350

Anti-NOVA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-11324R-A350)
Supplier: Bioss
Description: Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4782R-CY5

Anti-HSPB2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-4782R-CY5)
Supplier: Bioss
Description: The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. HSPB2 (heat shock 27 kDa protein 2), also known as HSP 27 or MKBP, is a 182 amino acid protein that belongs to the heat shock protein family and is expressed preferentially in heart and skeletal muscle. Localized to mitochondria, HSPB2 functions as an ATP-dependent chaperone protein that plays a role in the refolding of denatured proteins and may also interact with the Actin cytoskeleton and prevent apoptotic cell death. HSPB2 is abundantly expressed in several cancer cell lines, suggesting that HSPB2 may be an important factor in tumor transformation and metastasis.
UOM: 1 * 100 µl
Product Image-PIER26099

PEGylated N-succinimidyl S-acetylthioacetate, SAT(PEG)4, Pierce™

Catalog Number: (PIER26099)
Supplier: Thermo Fisher Scientific
Description: Pierce™ SAT(PEG)₄ (PEGylated N-succinimidyl S-acetylthioacetate) is a sulphhydryl-addition reagent for covalent modification of primary amines.
UOM: 1 * 100 mg
Image Unavailable-BOSSBS-8460R-CY3

Anti-FNDC1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-8460R-CY3)
Supplier: Bioss
Description: FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-PIER31007

Maleimide-activated protein, NeutrAvidin™ Pierce™

Catalog Number: (PIER31007)
Supplier: Thermo Fisher Scientific
Description: Thermo Scientific™ Maleimide Activated NeutrAvidin™ Protein is a specially-prepared form of avidin that decreases background in biotin-binding.
UOM: 1 * 5 mg
Image Unavailable-BOSSBS-5966R

Anti-LMO4 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-5966R)
Supplier: Bioss
Description: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5966R-CY7

Anti-LMO4 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-5966R-CY7)
Supplier: Bioss
Description: The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3860R-A350

Anti-CHRDL2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-3860R-A350)
Supplier: Bioss
Description: CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. Amember of the chordin family of proteins, it contains a signal peptide andthree CR (cysteine-rich repeat) domains. When expressed as a recombinantprotein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3860R-CY5.5

Anti-CHRDL2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-3860R-CY5.5)
Supplier: Bioss
Description: CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. Amember of the chordin family of proteins, it contains a signal peptide andthree CR (cysteine-rich repeat) domains. When expressed as a recombinantprotein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3860R-HRP

Anti-CHRDL2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-3860R-HRP)
Supplier: Bioss
Description: CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. Amember of the chordin family of proteins, it contains a signal peptide andthree CR (cysteine-rich repeat) domains. When expressed as a recombinantprotein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
UOM: 1 * 100 µl
Image Unavailable-CAYM24615-50

Human Recombinant PAD6 (from Baculovirus)

Catalog Number: (CAYM24615-50)
Supplier: Cayman Chemical
Description: Protein arginine deiminase 6 (PAD6) is a homodimeric guanidine-modifying enzyme belonging to the amidinotransferase superfamily. It is a calcium-dependent enzyme that catalyzes the post-translational modification of target proteins by converting arginine to citrulline. PAD6 is expressed in mammalian oocytes, sperm cells, and early embryos. In mammalian oocytes and early embryo cytoplasm, its expression is localized to cytoskeletal sheets, dynamic structures containing various keratins, which are major targets for citrullination. PAD6-/- oocytes exhibit reduced microtubule acetylation and defective organelle positioning and redistribution, suggesting a role for PAD6 in regulating microtubule-mediated organelle movement and positioning. PAD6-/- female, but not male, mice are infertile due to a reduction of de novo protein synthesis, cytoskeletal sheet formation, and ribosomal RNA which induces arrest of zygote development at the two-cell stage. PAD6 is regulated by newborn ovary homeobox (Nobox), as its promoter contains a Nobox DNA-binding element (NBE) and expression and activity of PAD6 are decreased in Nobox-/- mouse ovaries.5 In human females, homozygous nonsense mutations and compound-heterozygous mutations in PAD6 induce early embryonic arrest following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).
UOM: 1 * 50 µG
Image Unavailable-BOSSBS-11619R-CY3

Anti-RTP3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-11619R-CY3)
Supplier: Bioss
Description: Members of the RTP (receptor transporter proteins) family have recently been discovered to influence bitter taste receptor expression in addition to inducing the expression of mammalian odorant receptors. RTP3 is a 232 amino acid single-pass type III membrane protein belonging to the TMEM7 family. Unlike other RTP proteins, RTP3 is not expressed in olfactory neurons but is expressed predominantly in liver. RTP3 is involved in the functional expression of bitter taste receptors and suppresses cell proliferation, and is also found in human circumvallate papillae and testis (regions where bitter taste receptors are expressed). The gene encoding RTP3 maps to human chromosome 3p21.31 within C3CER1 (chromosome 3 common eliminated region 1), which is frequently eliminated in chromosomal deletions of solid tumors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11619R-A488

Anti-RTP3 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-11619R-A488)
Supplier: Bioss
Description: Members of the RTP (receptor transporter proteins) family have recently been discovered to influence bitter taste receptor expression in addition to inducing the expression of mammalian odorant receptors. RTP3 is a 232 amino acid single-pass type III membrane protein belonging to the TMEM7 family. Unlike other RTP proteins, RTP3 is not expressed in olfactory neurons but is expressed predominantly in liver. RTP3 is involved in the functional expression of bitter taste receptors and suppresses cell proliferation, and is also found in human circumvallate papillae and testis (regions where bitter taste receptors are expressed). The gene encoding RTP3 maps to human chromosome 3p21.31 within C3CER1 (chromosome 3 common eliminated region 1), which is frequently eliminated in chromosomal deletions of solid tumors.
UOM: 1 * 100 µl
Image Unavailable-ICNA0215389105

Protein A from Staphylococcus aureus, MP Biomedicals

Supplier: MP Biomedicals
Description: Protein A is a recombinant Fc-binding protein from <i>Staphylococcus aureus</i>, Cowan strain-1 gene. The product is a carboxy truncated material containing 301 amino acid residues. The non-binding regions have been removed to minimise potenial steric interference.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
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