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Image Unavailable-BOSSBS-6124R-A350

Anti-NBN Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-6124R-A350)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6124R-CY5.5

Anti-NBN Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-6124R-CY5.5)
Supplier: Bioss
Description: Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
UOM: 1 * 100 µl
Product Image-620-1665

VWR® Traceable® Ultra, Digital Dial Thermometers

Catalog Number: (620-1665)
Supplier: VWR Collection
Description: Dial thermometer for use in soil, cuvettes, test tubes, food products, incubators, biomedical reagents and petroleum hydrocarbons.
UOM: 1 * 1 items
Image Unavailable-D7008-10MG

Dihydroethidium ≥95%, Sigma-Aldrich®

Catalog Number: (D7008-10MG)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: Redox indicator. Blue fluorescence until oxidized to ethidium. Dihydroethidium has been used as a superoxide probe in bovine pulmonary artery endothelial cell (BPAEC).
UOM: 1 * 10 mg
Image Unavailable-ENZOENZ40847

JC virus BioProbe®

Catalog Number: (ENZOENZ40847)
Supplier: ENZO LIFE SCIENCES
Description: The JC Virus BioProbe® labeled probe is prepared by nick translation of a clone of the entire JC virus genome. JC virus, a member of the papovavirus family, usually causes subclinical infections. However, in immunocompromised individuals it can cause a fatal demyelinating brain disease, progressive multifocal leukoencephalopathy. JC virus is also neurooncogenic in primates. Fragment size range: 100-1000 base pairs (as estimated by agarose gel electrophoresis).
UOM: 1 * 2 µG
Image Unavailable-201626-1G

5-Aminofluorescein (isomer I), Sigma-Aldrich®

Supplier: SIGMA ALDRICH MICROSCOPY
Description: Fluoresceinamine, isomer I has been used as a probe in immobilization and is used to determine its ability to potentiate the antiviral activity of poly r (A-U).

Product Image-TEST0560.1110

Digital mini penetration thermometer

Catalog Number: (TEST0560.1110)
Supplier: Testo
Description: This mini penetration thermometer is used for measuring liquid temperatures in the laboratory, or air temperatures in heating and ventilation technology. It can also be used as a food thermometer. Its penetration probe is excellent for measuring the core temperature of food products during food controls.
UOM: 1 * 1 items
Product Image-31016-1

Fast probe master mixes

Supplier: Biotium
Description: A qPCR master mix containing Cheetah™ Taq hotstart DNA polymerase, suitable for probe-based real-time PCR applications.

MSDS

Image Unavailable-TEST0520.0166

ISO Humidity Calibration Certificate

Catalog Number: (TEST0520.0166)
Supplier: Testo
Description: This ISO calibration certificate certifies that your measuring instrument or probe is calibrated. Calibration is carried out according to the ISO standard.
UOM: 1 * 1 items
Product Image-F-531L

Phusion® High-Fidelity PCR Master Mix with HF Buffer

Supplier: FINNZYMES REAGENTS
Description: Phusion® High-Fidelity PCR Master Mix with HF Buffer is a convenient 2X mix containing Phusion® DNA Polymerase, nucleotides and optimised HF buffer including MgCl₂. Only template and primers need to be added by the user.

Product Image-432-0199

Accessories for Q500/Q700 Sonicators

Supplier: QSONICA LLC
Description: Microtip probes 1/4" (6,4 mm) for processing volume 10 - 50 ml, For: Q500/Q700 Sonicators

Image Unavailable-40064.

Cyanine 555-dUTP, lyophilised red solid

Catalog Number: (40064.)
Supplier: Biotium
Description: Cyanine 555-dUTP can be used to synthesise labeled DNA probes for in-situ hybridization, microarray or blotting techniques.
UOM: 1 * 25 Nmo
Product Image-620-2395

Anemometers, smart and wireless probes, testo 405i/410iand VAC kit operated with smartphone

Supplier: Testo
Description: These Smart Probes are designed to be used with smartphones and tablets. Users can read the measurements using the testo Smart Probes App installed on their smart device. The App allows you to remotely read measurements from up to six Smart Probes and easily document/report the results. All measurement data is displayed as instrument readings, tables, or graphs. The measurements can be quickly saved as PDF or Excel files. The App creates custom reports which can be saved and/or shared by email. The app works on smart devices with either Android or Apple operating systems (requires iOS 8.3 or newer; requires Android 4.3 or newer; requires mobile end device with Bluetooth 4.0.).

Product Image-620-1384

Core thermometer, TTX 110

Catalog Number: (620-1384)
Supplier: EBRO
Description: Thermocouple thermometer with fixed probe (Type T).
UOM: 1 * 1 items
Product Image-TEST0563.4406

Air flow comboKit 1 with Bluetooth®, Testo 440

Catalog Number: (TEST0563.4406)
Supplier: Testo
Description: Airflow Combokit 1 equipped with clearly structured measurement menu for volume flow and parallel determination of air velocity, differential pressure, humidity and temperature in ventilation ducts or at ventilation outlets.
UOM: 1 * 1 items
Product Image-620-2809

VWR® Traceable® Digital Heat Thermometer

Catalog Number: (620-2809)
Supplier: VWR Collection
Description: Simultaneously displays temperature, timer, and current alarms.
UOM: 1 * 1 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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