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Image Unavailable-BOSSBS-6144R-A680

Anti-PRMT4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-6144R-A680)
Supplier: Bioss
Description: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilising properties and the half-life of their target mRNAs.
UOM: 1 * 100 µl
Product Image-PRSI7219

Anti-CARM1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI7219)
Supplier: ProSci Inc.
Description: CARM1 Antibody: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation. CARM1 functions as a transcriptional co-activator for various nuclear receptors and NF-κB. It has also been shown to methylate histone H3 arginines, inhibiting the binding of corepressors and protecting chromatin from deacetylation, thereby facilitating transcription.
UOM: 1 * 100 µG
Product Image-115-2399

VWR®, Industrial Wipes, Raspy

Supplier: VWR Collection
Description: These spunlace apertured wipes, made from 51% wood pulp and 49% polyester, are slightly abrasive on one side and soft on the other.

Product Image-BARN88880028

Digital heating shaking block heater

Catalog Number: (BARN88880028)
Supplier: Thermo Fisher Scientific
Description: This can be used as a drybath, shaker or both. The wide temperature range covers a broad range of applications including thawing, incubation, enzyme reactions, blood urea nitrogen determinations, and immunoassays.
UOM: 1 * 1 items
Image Unavailable-APOSOR939181-1G

BrettPhos palladacycle 3rd generation

Supplier: Apollo Scientific
Description: BrettPhos palladacycle 3rd generation

Product Image-705-0791

Kjeldahl Digestion Units, Automatic, DKL

Supplier: VELP SCIENTIFIC
Description: Fully automatic Kjeldahl digestion units for nitrogen analysis and protein determination that incorporate the TEMS™ technology for savings in terms of time, energy (as much as 35%), money and space. The unit also includes an aluminium block for absolute temperature homogeneity and shows excellent conductivity for fast response up to 450 °C. The unit has an LCD with real time display of process steps and the choice of up to six languages. There are 54 programs available of which 30 are pre-installed and 24 user-defined programs. All necessary items are supplied in one package.

Product Image-713-4038

Cuvette tests for water testing for WTW spectrophotometers and photometers

Supplier: WTW
Description: A wide choice of tests is available, for routine quantitative analysis in different applications, designed for use with WTW spectrophotometers and photometers. The test is automatically recognised by the laboratory instruments (via a barcoding system) and results are displayed in the appropriate units. Due to the different photometer optics, one test may yield different measuring ranges in different instruments; LED photometers may have smaller measuring ranges for the same test.

Product Image-241-0015

VWR®, Clamps, Three Pronged

Catalog Number: (241-0015)
Supplier: VWR Collection
Description: Laboral aluminium alloy.
UOM: 1 * 5 items
Product Image-115-1660

Wipes for general applications, Tork Heavy-Duty

Supplier: Essity
Description: Cellulose/PP/polyester, reusable. These low-linting and textured cloths have been specially designed for heavy-duty cleaning and degreasing tasks.

Image Unavailable-ICNA0219485794

Urea ≥98%, white powder for molecular biology

Supplier: MP Biomedicals
Description: Applications:
Urea is used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies and in the extraction of the mitochondrial complex. It is commonly used to solubilize and denature proteins for denaturing isoelectric focusing and two-dimensional electrophoresis and in acetic acid-urea PAGE gels. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form. Urea is used in cell or tissue culture media to increase the osmolality. Urea has also been used as fertilizer because of the easy availability of nitrogen; in animal feeds; it is reacted with aldehydes to make resins and plastics; condensed with malonic ester to form barbituric acid; used in the paper industry to soften cellulose.
Biochem/physiol Actions:
Urea has been shown to act as an aldosterone antagonist in the development of peanut agglutinin binding in cultured embryonic renal collecting duct epithelial cells. Urea is the principal end product of nitrogen metabolism in most mammals, formed by the enzymatic reactions of the Kreb's cycle.
Typical Working Concentration:
The use of 2 g/L urea in the culture of Kluyveromyces marxianus to produce a thermostable extracellular lipase has been described. Urea is typically used at a concentration of 8 M for protein denaturation or solubilization. A final concentration of 5 M urea is commonly used in molecular biology for sequencing gels. To prevent carbamylation, do not heat urea containing buffers above 37 °C

Image Unavailable-47250.MD

BrettPhos palladacycle 3rd generation 98%

Supplier: Thermo Fisher Scientific
Description: BrettPhos palladacycle 3rd generation 98%

Product Image-115-0338

Wipes for general applications, Tork

Supplier: Essity
Description: Strong and durable cloth wipes for use in a variety of environments, softness and flexibility mean wipes are excellent for cleaning, wiping and polishing even in confined spaces.

Product Image-115-2417

VWR®, Industrial Wipes, Super Soft

Catalog Number: (115-2417)
Supplier: VWR Collection
Description: These very soft wipes, made from a spunlace fabric, consisting of 60% viscose and 40% polyester, are ideal for sensitive surfaces and light duty cleaning.
UOM: 1 * 500 items
Product Image-115-0604

Wipes for general applications, WYPALL® X80

Supplier: KIMBERLY CLARK
Description: WYPALL® X80 Cloth is fast absorbing thanks to the unique non woven HYDROKNIT® material. These bulky, reusable cloth-like wipes have an excellent absorption capacity.

Image Unavailable-ICNA0219398105

Tritirachium album proteinase K, MP Biomedicals

Supplier: MP Biomedicals
Description: Proteinase K is a highly active stable endopeptidase with a broad spectrum of action was isolated by E. Merk's Darmstadt Biochemical Research Department in 1970 from a culture filtrate of the fungus, Tritirachium album Limber. This fungus is able to grow on Keratin (e.g., wool, horn particles) as the sole source of carbon and nitrogen. The isolated protease was, therefore, given the K designation.
Proteinase K is a stable and highly reactive serine protease. Evidence from crystal and molecular structure studies indicates the enzyme belongs to the subtilisin family with an active-site catalytic triad (Asp39-His69-Ser224). It is stable in a broad range of environments: pH, buffer salts, detergents (SDS), and temperature. In the presence of 0,1 to 0,5% SDS, proteinase K retains activity and will digest a variety of proteins and nucleases in DNA preparations without compromising the integrity of the isolated DNA.

Certificates

Product Image-241-0029

VWR®, Clamps, Four Pronged

Catalog Number: (241-0029)
Supplier: VWR Collection
Description: Stainless steel.
UOM: 1 * 2 items
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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