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N-Acetylneuraminic acid methyl ester 97% min

Supplier: Apollo Scientific
Description: N-Acetylneuraminic acid methyl ester 97% min

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Human recombinant sialate O-Acetylesterase (from cells)

Catalog Number: (PRSI91-729)
Supplier: ProSci Inc.
Description: Sialate O-Acetylesterase (SIAE) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. SIAE is widely expressed with high expression levels in the testis, prostate, and colon. SIAE catalyses N-acetyl-O-acetylneuraminate and H2O to N-acetylneuraminate and acetate. SIAE removes O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid. SIAE down-regulates B lymphocyte antigen receptor signaling (involving CD22), and is required for immunological tolerance. Loss of function mutations in SIAE are much more frequently found in humans with autoimmune diseases especially rheumatoid arthritis and type 1 diabetes.
UOM: 1 * 50 µG

Bürkle single-use powder and liquid funnels

Cleanroom manufactured funnels, a practical and hygienic pouring aid! Also available sterile (10-6). Made of PS, compliant to EU food and FDA regulations.

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A truly clean filling aid for your lab

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N-Acetylneuraminic acid 97%

Supplier: Apollo Scientific
Description: N-Acetylneuraminic acid 97%

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Supelco® Organic Reference Standard, N-Acetylneuraminic Acid

Catalog Number: (19023-10MG)
Supplier: Merck
Description: Organic Standard, N-Acetylneuraminic acid
UOM: 1 * 10 mg
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N-Acetylneuraminic acid 98%

Supplier: Apollo Scientific
Description: N-Acetylneuraminic acid 98%

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5-Bromo-4-chloro-3-indolyl-α-D-N-acetylneuraminic acid

Catalog Number: (APOSOR8230T-5MG)
Supplier: Apollo Scientific
Description: A substrate for the detection of sialidase-like enzyme,screening of enzymes, studying the physiological role of gangliosides, & for recombinant technologies.
UOM: 1 * 5 mg
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N-Acetylneuraminic acid 97%

Supplier: Thermo Scientific
Description: N-Acetylneuraminic acid 97%

MSDS Certificates

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N-Acetylneuraminic acid ≥97% (by HPLC)

Catalog Number: (ENZOALX305010M250)
Supplier: ENZO LIFE SCIENCES AG
Description: N-Acetylneuraminic acid ≥97% (by HPLC)
UOM: 1 * 250 mg

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N-Acetylneuraminic acid 99%

Supplier: Thermo Scientific
Description: Appearance: White to off-white Powder

MSDS

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2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate

Supplier: Apollo Scientific
Description: 2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate

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5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt

Supplier: Apollo Scientific
Description: 5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminic acid sodium salt

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N-Acetylneuraminic Acid, Reference Standard

Catalog Number: (1612619.)
Supplier: USP
Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
UOM: 1 * 200 mg
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Anti-GLCNE Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-9882R-A680)
Supplier: Bioss
Description: The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk), or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. GLCNE is required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumourigenicity and metastatic behavior of malignant cells. It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta. It is also expressed, to a lesser extent, in heart, brain, lung, kidney, skeletal muscle and pancreas. Defects in GLCNE are the cause of sialuria, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV). Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, resulting in overproduction of NeuAc. It is characterised by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine. Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterised by adult onset, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9882R-A750

Anti-GLCNE Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-9882R-A750)
Supplier: Bioss
Description: The bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/Mnk), or GLCNE, regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. GLCNE is required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumourigenicity and metastatic behavior of malignant cells. It is upregulated after PKC-dependent phosphorylation and is most abundantly expressed in liver and placenta. It is also expressed, to a lesser extent, in heart, brain, lung, kidney, skeletal muscle and pancreas. Defects in GLCNE are the cause of sialuria, inclusion body myopathy 2 (IBM2) and Nonaka myopathy (NM) or distal myopathy with rimmed vacuoles (DMRV). Sialuria is an autosomal dominant disorder caused by a lack of feedback inhibition of GLCNE by CMP-NeuAc, resulting in overproduction of NeuAc. It is characterised by an accumulation of free sialic acid in the cytoplasm and large quantities of neuraminic acid in the urine. Both IBM2 and NM/DMRV are autosomal recessive neuromuscular disorders characterised by adult onset, distal and proximal muscle weakness (especially in the legs) and a typical muscle pathology including filamentous inclusions and rimmed vacuoles.
UOM: 1 * 100 µl
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Anti-RBC Rabbit Polyclonal Antibody

Catalog Number: (ROCK113-4139)
Supplier: Rockland Immunochemicals
Description: Anti-Sheep Red Blood Cell Antibody may be used in hemagglutination assays. Haemagglutination assay or HA is a method of quantification for viruses or bacteria by hemagglutination. Some viral families and many bacteria have envelope or surface proteins which are able to agglutinate (stick to) human or animal red blood cells (RBC) and bind to N-acetylneuraminic acid. As each of the agglutinating molecule attaches to multiple RBCs, a lattice-structure will form. Normally, a virus dilution (e.g. 2-fold from 1:4 to 1:4096) will be applied to an RBC dilution (e.g. 0.1% to 0.7% in steps of 0.2%) for approx. 30 min, often at 4° C, otherwise viruses with neuraminidase activity will detach the virus from the RBCs. Then the lattice forming parts will be counted and the titer calculated. The titer of a hemagglutination assay is determined by the last viable "lattice" structure found. This is because it is at the point where, if diluted anymore, the amount of Virus particles will be less than that of the RBCs and thus not be able to agglutinate them together. Anti-SHEEP Red Blood Cell Antibody is used to sensitize erythrocytes and quantitate agglutination.
UOM: 1 * 2 mL
Image Unavailable-ROCK103-4139

Anti-RBC Rabbit Polyclonal Antibody

Catalog Number: (ROCK103-4139)
Supplier: Rockland Immunochemicals
Description: Anti-Chicken Red Blood Cell Antibody may be used in hemagglutination assays. Haemagglutination assay or HA is a method of quantification for viruses or bacteria by hemagglutination. Some viral families and many bacteria have envelope or surface proteins which are able to agglutinate (stick to) human or animal red blood cells (RBC) and bind to N-acetylneuraminic acid. As each of the agglutinating molecule attaches to multiple RBCs, a lattice-structure will form. Normally, a virus dilution (e.g. 2-fold from 1:4 to 1:4096) will be applied to an RBC dilution (e.g. 0.1% to 0.7% in steps of 0.2%) for approx. 30 min, often at 4° C, otherwise viruses with neuraminidase activity will detach the virus from the RBCs. Then the lattice forming parts will be counted and the titer calculated. The titer of a hemagglutination assay is determined by the last viable "lattice" structure found. This is because it is at the point where, if diluted anymore, the amount of Virus particles will be less than that of the RBCs and thus not be able to agglutinate them together. Anti-CHICKEN Red Blood Cell Antibody is used to sensitize erythrocytes and quantitate agglutination.
UOM: 1 * 2 mL
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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