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Image Unavailable-BOSSBS-4107R-FITC

Anti-HLA-DPB1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-4107R-FITC)
Supplier: Bioss
Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4107R-CY3

Anti-HLA-DPB1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-4107R-CY3)
Supplier: Bioss
Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4107R-A350

Anti-HLA-DPB1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-4107R-A350)
Supplier: Bioss
Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface.
UOM: 1 * 100 µl
Product Image-MSPP66081-1-IG

Anti-IFITM3 Mouse Monoclonal Antibody [clone: 2E8D12]

Catalog Number: (MSPP66081-1-IG)
Supplier: MARKET SOURCE PART PROCESS
Description: IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterised early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. This antibody recognises both IFITM2 and IFITM3.
UOM: 1 * 150 µl

Market Source Item This is a MarketSource item. Additional charges may apply

Image Unavailable-BOSSBS-4107R-CY5

Anti-HLA-DPB1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-4107R-CY5)
Supplier: Bioss
Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4107R-A680

Anti-HLA-DPB1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-4107R-A680)
Supplier: Bioss
Description: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilises MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. .
UOM: 1 * 100 µl
Image Unavailable-MSPPS/3760/53-500G

Sodium dihydrogen phosphate dihydrate

Catalog Number: (MSPPS/3760/53-500G)
Supplier: MARKET SOURCE PART PROCESS
Description: Sodium dihydrogen phosphate dihydrate
UOM: 1 * 500 g

Market Source Item This is a MarketSource item. Additional charges may apply

Product Image-1.07736.2500

Silica gels for TLC and PLC plates, standardised

Supplier: Merck
Description: Selection of standardised and modified silica gels that are available in many granulations and supplied from one single source, dedicated to chromatography. Standardised silica gels are widely used in separation processes to purify valuable compounds in ton quantities.

MSDS

Image Unavailable-631-0918

Spare Parts for SCHOTT KL Cold Light Sources

Supplier: SCHOTT AG Lighting and imaging
Description: An assortment of spare parts are still available for older model cold light sources, including the KL200, KL1500e, KL1500 compact, KL1500LCD and KL2500LCD.

Image Unavailable-21603-5G

Disperse Orange 37, Sigma-Aldrich®

Catalog Number: (21603-5G)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: Disperse Orange 37 may be used during an experimental study conducted to understand the mutagenic and carcinogenic potential of textile azo dye processing plant effluent, that is known to have an impact on drinking water source.
UOM: 1 * 5 g
Product Image-S4200-100

Human sera

Supplier: Biowest
Description: Human serum 'off-the-clot' is processed from human blood that has been coagulation-induced. It is collected from volunteer donors.

MSDS Certificates

Product Image-129-2877

Polypropylene Bowl Covers

Supplier: KEYSTONE CLEANROOM PRODUCTS
Description: Keeps cleaned, non sterile production equipment surfaces protected from external sources of contamination; or use ‘in process’ to prevent cross contamination of products.

Product Image-MFLX07575-01

Masterflex® L/S® Digital Console Process Drive Replacement Seal Kit, Avantor®

Catalog Number: (MFLX07575-01)
Supplier: Avantor Fluid Handling
Description: Make the most of your Masterflex drives replacement parts and other accessories.
UOM: 1 * 1 items
Product Image-MILFMSNU03050

MultiScreen® PCR 96 Filter Plates

Supplier: Merck
Description: The polymerase chain reaction (PCR) is a highly effective fundamental technique in molecular biology. It offers a fast and efficient way to amplify specific DNA or RNA sequences from nucleic acids derived from different sources using enzymatic processes in a laboratory setting.

Product Image-1920-01

Dextrose, anhydrous 97.5-102.0% (by anhydrous basis) USP, Multi-Compendial, J.T.Baker®

Supplier: Avantor
Description: Dextrose multi-compendial.
Make upstream processing steps more reliable and productive with pharmaceutical sugars from Avantor™ Performance Materials. These products are a reliable source of carbon and energy for cell cultures, and used as excipients, effectively stabilize valuable and delicate lyophilized proteins for injectable biopharmaceutical drugs.

MSDS Certificates

Image Unavailable-1.07729.9025

Silica gels for preparative chromatography, standardised and modified

Supplier: MERCK PRODUCTION CHEMICALS
Description: Selection of Merck's standardised and modified silica gels that are available in many granulations and supplied from one single source, dedicated to chromatography. Standardised silica gels are widely used in separation processes to purify valuable compounds in ton quantities. Modified silica on the other hand is used in separation problems, which cannot be adequately solved using unmodified silica.

MSDS

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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