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Product Image-PRSI36-322

Anti-NLRP1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI36-322)
Supplier: ProSci Inc.
Description: NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
UOM: 1 * 100 µG
Image Unavailable-SPCMMA147-500GM

DL-Malic acid ≥99.0% FCC

Catalog Number: (SPCMMA147-500GM)
Supplier: Spectrum Chemical
Description: Malic Acid, FCC is used as a source of extreme tartness. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
UOM: 1 * 500 g
Product Image-PRSI96-409

Human recombinant interferon gamma (from HEK293 cells)

Catalog Number: (PRSI96-409)
Supplier: ProSci Inc.
Description: Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.
UOM: 1 * 100 µG
Product Image-620-2819

Calibrated thermocouple thermometers, H-B Durac®

Supplier: Bel-Art Products, a Part of SP
Description: Used for temperature measurement in life science research, kilns, gas turbine exhaust, diesel engines, and other industrial processes, H-B calibrated thermocouple thermometers provide measurement throughout a broad temperature range and the ability to utilise multiple probes at the same time.

Product Image-BELAB602020100

Environmentally friendly thermometer, individually calibrated, Enviro-Safe®, SP Bel-Art

Catalog Number: (BELAB602020100)
Supplier: Bel-Art Products, a Part of SP
Description: Each easy to read thermometer includes an individualised thermometer calibration report stating corrections to one-tenth of the smallest division, unique report number and NIST standards used for the calibration. Ideal for use in chemical/petrochemical laboratories, universities, scientific institutions, food and beverage processing, pharmaceutical and medical industries, dairies, breweries and distilleries.
UOM: 1 * 1 items
Product Image-181-0310

VWR® VP 220, Chemical Duty, High Performance Diaphragm Pump

Catalog Number: (181-0310)
Supplier: VWR Collection
Description: The VP 220 is ideal for rotary evaporators providing the powerful vacuum needed for demanding evaporations without the use of oil pumps. VP 220 has built-in Advanced Vapour Management (AVM) which means precise control capability for the distillation of organic solvents and applications handling aggressive vapours and gases. The VP 220 is especially effective for rotary evaporation of low boiling point solvents such as acetone and ethanol and is able to rapidly strip DMF at 35 °C. The pump parts are all made of corrosion resistant materials such as PTFE and Kalrez to handle aggressive vapours, and together with vacuum adjustment, the evaporation process will be optimised. Use the vacuum adjustment to increase the vacuum until bubbles form in the evaporation flask - then lower it slightly. Reduce the vacuum for fast reaction to bumping or foaming.
UOM: 1 * 1 items
Product Image-PRSI29-275

Anti-HNRNPL Rabbit Polyclonal Antibody

Catalog Number: (PRSI29-275)
Supplier: ProSci Inc.
Description: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions.Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
UOM: 1 * 50 µG
Product Image-PRSI29-274

Anti-HNRNPL Rabbit Polyclonal Antibody

Catalog Number: (PRSI29-274)
Supplier: ProSci Inc.
Description: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.
UOM: 1 * 100 µG
Product Image-444-1130

Orbital shakers, Solaris™ 2000 and 4000

Supplier: Thermo Fisher Scientific
Description: Solaris orbital shakers are reliable and innovative. Ruggedly built for demanding use, they combine an ergonomic design with key feature enhancements that help save time and protect your process. The triple-eccentric drive mechanism is built with proven technology to easily support heavy loads. The belt is maintenance-free and engineered to last the life of the shaker, and the shaker mechanism itself comes with a full 2 year warranty, 5 year warranty on parts and 10 years on the drive mechanism.

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Product Image-620-2342

Maximum registering, autoclave bi-metallic thermometers, SP Bel-Art

Catalog Number: (620-2342)
Supplier: Bel-Art Products, a Part of SP
Description: This durable thermometer, with maximum registering pointer (red), is moved up by the temperature measuring pointer (black) to indicate the highest temperature. The threaded connection (¼" NPT) screws into processes and can be used to mount thermometer on included stand.
UOM: 1 * 1 items

Certificates


Product Image-PRSI96-317

Human recombinant Fgfr 4 (from HEK293 cells)

Catalog Number: (PRSI96-317)
Supplier: ProSci Inc.
Description: Fibroblast growth factor receptor 4(FGFR4) is also known as CD334, JTK2, hydroxyaryl-protein kinase, TKF, protein-tyrosine kinase . The FGFR4 gene provides instructions for making a protein called fibroblast growth factor receptor 4. This protein is part of a family of fibroblast growth factor receptors that share similar structures and functions. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development.The FGFR4 protein interacts with specific growth factors to conduct signals from the environment outside the cell to the nucleus. The nucleus responds to these signals by switching on or off appropriate genes that help the cell adjust to changes in the environment. In response, the cell might divide, move, or mature to take on specialized functions. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. The FGFR4 gene may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
UOM: 1 * 200 µG
Product Image-PRSI50-266

Anti-NOP1 Mouse Monoclonal Antibody

Catalog Number: (PRSI50-266)
Supplier: ProSci Inc.
Description: Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5 kDa), is essential for yeast viability, and is localized in the nucleoli. The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34 kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6).
UOM: 1 * 100 µl
Image Unavailable-PRSI33-724

Anti-FLI1 Mouse Monoclonal Antibody [clone: SPM181]

Catalog Number: (PRSI33-724)
Supplier: ProSci Inc.
Description: Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.<p>Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum corneum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alternatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum corneum to release free amino acids that assist in water retention. [Wiki].
UOM: 1 * 100 µG

New Product


Product Image-1.04141.0001

Lateral Flow test for E. coli, Singlepath® E. coli O157 and Duopath® Verotoxins

Catalog Number: (1.04141.0001)
Supplier: Merck
Description: EHEC is capable of inducing life threatening illnesses, particularly in people with immune deficiency, young children and the elderly. Although the most common cause of EHEC is <i>E. coli</i> O157, other serotypes, such as O26, O45, O103, O111, O121 and O145, are also relatively frequent causes of infection. Typical symptoms are severe abdominal pain and diarrhoea, which is initially watery but often becomes bloody. <i>E. coli</i> are gram-negative, non sporulating, facultative anaerobic bacilli. Amongst the pathogenic <i>E. coli</i>, Verotoxin-forming strains (STEC or VTEC) have gained importance in recent years. The group of enterohaemorrhagic <i>E. coli</i> (EHEC) with its highly pathogenic serovar O157:H7 strain is particularly interesting in this respect. The main sources of infection are contaminated, raw or insufficiently heated foods of animal origin, such as meat and dairy products. The reservoir for EHEC is the gut of ruminants. Microorganisms can enter food during the processing of meat and dairy products if hygienic conditions are inadequate. The drastic increase in the incidence of food contamination caused by <i>E. coli</i> O157 demands reliable and rapid methods of detection. Innovative, rapid tests make screening for pathogenic organisms easier. Complete test sets for the detection of pathogens and toxins. The one-step format reduces the possibility of errors during handling. In addition to tests for the most common cause of infection, <i>E. coli</i> O157, there exits a 24-H screening protocol for VTEC, including <i>E. coli</i> O104:H4, based on Rapidcult™ <i>E. coli</i> enrichment combined with detection using Duopath® Verotoxins.
UOM: 1 * 25 Tests

MSDS


Product Image-PRSI55-175

Anti-ATP6V0B Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-175)
Supplier: ProSci Inc.
Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
UOM: 1 * 400 µl

New Product


Product Image-PRSI29-367

Anti-PCBP1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI29-367)
Supplier: ProSci Inc.
Description: PCBP1 appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. PCBP1 is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to be generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly (rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM: 1 * 50 µG
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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