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Image Unavailable-BOSSBS-2006R-A647

Anti-PCNA-proliferation Marker Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-2006R-A647)
Supplier: Bioss
Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
UOM: 1 * 100 µl
Image Unavailable-ENZOENZ33808

In-situ hybridisation buffer (1.25X concentrate), Enzo Life Sciences

Catalog Number: (ENZOENZ33808)
Supplier: ENZO LIFE SCIENCES
Description: In Situ Hybridization Buffer provides a high quality hybridization medium for in situ hybridization analyses using either DNA or oligonucleotide probes labeled with biotin-, digoxigenin- or fluorescein-modified nucleotides.
UOM: 1 * 10 mL
Image Unavailable-50033.

Fura 2-AM ≥98% (by HPLC) fluorescent indicator, for calcium determination

Supplier: Biotium
Description: Fura-2, AM ester is a ratiometric fluorescent dye that binds to free intracellular calcium, and is the preferred dye for ratiometric imaging microscopy. Fura-2, AM ester is membrane-permeant and thus can be loaded into cells via incubation.

Image Unavailable-50029.

Fura 2-AM 1 mM in anhydrous DMSO fluorescent indicator, for calcium determination

Catalog Number: (50029.)
Supplier: Biotium
Description: Fura-2, AM ester is a ratiometric fluorescent dye that binds to free intracellular calcium, and is the preferred dye for ratiometric imaging microscopy. Fura-2, AM ester is membrane-permeant and thus can be loaded into cells via incubation.
UOM: 1 * 1 mL
Image Unavailable-TUTT210004XP

T-Classic Plus Gauged Autoclave

Supplier: TUTTNAUER
Description: The T-Classic plus gauged autoclave is ideal for effective sterilization at a higher temperature. Complete with gauges to show pressure and temperature, this autoclave is designed for laboratory use and with its simple one touch operation, it is guaranteed to meet your sterilization needs.

Image Unavailable-BOSSBS-2007R-A750

Anti-PCNA [Proliferation Marker] Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-2007R-A750)
Supplier: Bioss
Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesise across the lesion.
UOM: 1 * 100 µl
Product Image-786-033

Research buffers and reagents

Supplier: G-Biosciences
Description: These DNase- and RNase-free buffers and reagents are designed for high quality research.

Image Unavailable-BOSSBS-2006R-A750

Anti-PCNA-Proliferation Marker Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-2006R-A750)
Supplier: Bioss
Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesise across the lesion.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2006R-A488

Anti-PCNA-proliferation Marker Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-2006R-A488)
Supplier: Bioss
Description: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
UOM: 1 * 100 µl
Image Unavailable-50007.

5,5’-Dimethyl BAPTA AM ester ≥95% (by TLC) ion chelator, for calcium determination

Catalog Number: (50007.)
Supplier: Biotium
Description: Dimethyl BAPTA AM ester is a membrane permeable form of Dimethyl BAPTA that can be loaded into cells by incubation. Dimethyl BAPTA AM ester itself does not bind calcium, but once inside the cell is converted into Dimethyl BAPTA by cytoplasmic esterases.
UOM: 1 * 25 mg
Image Unavailable-ABCAAB184577-100

Anti-alpha Tubulin Mouse Monoclonal Antibody [clone: DM1A] (Alexa Fluor® 790)

Catalog Number: (ABCAAB184577-100)
Supplier: Abcam
Description: Anti-alpha Tubulin Mouse Monoclonal Antibody [clone: DM1A] (Alexa Fluor® 790)
UOM: 1 * 100 µG
Image Unavailable-59004.

Pluronic® F-127 20% in DMSO

Catalog Number: (59004.)
Supplier: Biotium
Description: Ready-to-use solution of Pluronic® F-127, a nonionic detergent useful for solubilizing hydrophobic dye molecules such as cell-permeable AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 calcium indicators to facilitate cell loading.
UOM: 1 * 1 mL

MSDS


Product Image-481-2004

Autoclaves, horizontal and vertical, fully automatic control, EL series

Catalog Number: (481-2004)
Supplier: TUTTNAUER
Description: Horizontal and vertical autoclave with automatic control. The chamber is constructed of long lasting 316L/Ti grade stainless steel with superior corrosion resistance; the generator is made from stainless steel.
UOM: 1 * 1 items
Product Image-HYCLSH30028.08

Dulbecco's phosphate buffered saline (DPBS), for cell culture, HyClone™

Supplier: HyClone products (Cytiva)
Description: Balanced salt solution used for multiple cell culture applications, (liquid form).

Image Unavailable-ROCKMB-059

TM Buffer, 1X Tris-Magnesium sulphate, pH 7,5

Catalog Number: (ROCKMB-059)
Supplier: Rockland Immunochemicals
Description: This product is ready-to-use as a working 1X solution and requires no further dilution. This buffer consists of 50 mM Tris HCl, 10 mM magnesium sulphate at pH 7,5 and was prepared using ultra pure reagents dissolved in pharmaceutical grade deionised water.
UOM: 1 * 1 L
Image Unavailable-ENZOBMLKI1170030

Caspase cell lysis buffer

Catalog Number: (ENZOBMLKI1170030)
Supplier: ENZO LIFE SCIENCES
Description: Caspase cell lysis buffer, Enzo Life Sciences
UOM: 1 * 30 mL
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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