You Searched For: L-Threonine

Catalog Number: (BOSSBS-2775R-A488)

Supplier: Bioss

Description: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).

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Catalog Number: (BOSSBS-12475R-HRP)

Supplier: Bioss

Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. ANKK1 (ankyrin repeat and kinase domain containing 1), also known as PKK2 or SGK288, is a 765 amino acid protein that belongs to the Ser/Thr protein kinase family and contains 12 ANK repeats and one protein kinase domain. Highly expressed in brain tissue and present in lower amounts in placenta and spinal cord, ANKK1 functions to catalyze the ATP-dependent phosphorylation of target proteins and is thought to play a role in alcohol and nicotine dependence. The gene encoding ANKK1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.

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Catalog Number: (BOSSBS-1427R-A750)

Supplier: Bioss

Description: IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B.

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Catalog Number: (BOSSBS-1427R-A680)

Supplier: Bioss

Description: IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B.

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Catalog Number: (BOSSBS-5675R-CY7)

Supplier: Bioss

Description: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

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Catalog Number: (BOSSBS-1509R-HRP)

Supplier: Bioss

Description: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

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Catalog Number: (USBIA4189-01K-HRP)

Supplier: US Biological

Description: Anti-AURKA Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

UOM: 1 * 200 µl

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Catalog Number: (USBIS1014-58Z1D-BI)

Supplier: US Biological

Description: Anti-SMG1 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

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Catalog Number: (USBIS1013-72H-PE)

Supplier: US Biological

Description: Anti-SIK1 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

UOM: 1 * 200 µl

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Catalog Number: (USBIS4283-34)

Supplier: US Biological

Description: Anti-SRPK3 Rabbit Polyclonal Antibody

UOM: 1 * 200 µl

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Catalog Number: (BOSSBS-11990R-A555)

Supplier: Bioss

Description: The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50% of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter-α and CAB39.

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Catalog Number: (BOSSBS-7597R-A750)

Supplier: Bioss

Description: The RIPK5 gene encodes a dual serine/threonine and tyrosine protein kinase that is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.

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Catalog Number: (USBIA0855-91D-HRP)

Supplier: US Biological

Description: Anti-ACVRL1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

UOM: 1 * 200 µl

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Catalog Number: (BOSSBS-9318R-CY5.5)

Supplier: Bioss

Description: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-9318R-CY5)

Supplier: Bioss

Description: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-9317R-A488)

Supplier: Bioss

Description: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression.

UOM: 1 * 100 µl

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