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Image Unavailable-BOSSBS-5387R-A555

Anti-HDAC1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-5387R-A555)
Supplier: Bioss
Description: Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5387R-A488

Anti-HDAC1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-5387R-A488)
Supplier: Bioss
Description: Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5387R-HRP

Anti-HDAC1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-5387R-HRP)
Supplier: Bioss
Description: Reversible acetylation of highly conserved lysine residues within the N-terminal tail domains of core histones, plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activities of histone acetyltransferases (HATs) and the competing enzymes histone deacetylases (HDACs). Histone deacetylases activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. Recruitment of the multiprotein complexes to promoter sites occurs by many sequence specific DNA-binding proteins such as unliganded nuclear hormone receptors, DP1-E2F, YY1 and Rb family of transcription factors, transcriptional repressors and tumor suppressors (e.g. BRCA1). Aberrant recruitment of HDACs by certain oncoproteins may occur in certain neoplastic diseases. Belongs to the histone deacetylase family.
UOM: 1 * 100 µl
Image Unavailable-ST1027-50

Anti-Acetylated Lysine Rabbit Polyclonal Antibody

Catalog Number: (ST1027-50)
Supplier: Merck Millipore (Oncogene)
Description: Anti-Acetylated Lysine Rabbit Polyclonal Antibody
UOM: 1 * 50 µl
Image Unavailable-QEDB56455

Anti-Acetylated Lysine Mouse Monoclonal Antibody

Catalog Number: (QEDB56455)
Supplier: QED Bioscience
Description: Anti-Acetylated Lysine Mouse Monoclonal Antibody
UOM: 1 * 100 µG
Image Unavailable-ANTIA305227-100

Anti-Acetylated Lysine Mouse Monoclonal Antibody [clone: 7F8]

Catalog Number: (ANTIA305227-100)
Supplier: ANTIBODIES.COM
Description: Anti-Acetylated Lysine Mouse Monoclonal Antibody [clone: 7F8]
UOM: 1 * 100 µG

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Image Unavailable-ENZOBMLKI1050300

Fluor-de-Lys® Developer I concentrate

Catalog Number: (ENZOBMLKI1050300)
Supplier: ENZO LIFE SCIENCES
Description: FLUOR DE LYS® Developer is an essential reagent for signal generation in HDAC or sirtuin assays done with the FLUOR DE LYS® substrate. An appropriate FLUOR DE LYS® family substrate, comprising an acetylated lysine side chain, is first incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes it so that, in a second step, treatment with the FLUOR DE LYS® Developer produces a fluorophore. Typically, an ‘inhibitor stop’ will be included in the 1x Developer dilution (e.g. Trichostatin A) for class I and II HDACs, nicotinamide for sirtuins).
UOM: 1 * 300 µl
Image Unavailable-ENZOBMLKI1040050

Fluor-de-Lys® Deacetylase Substrate

Catalog Number: (ENZOBMLKI1040050)
Supplier: ENZO LIFE SCIENCES
Description: Fluor de Lys® Substrate is a highly sensitive and convenient alternative to radiolabeled, acetylated histones or peptide/HPLC methods for the assay of histone deacetylases. The Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with a sample containing HDAC activity (nuclear or cellular extract, purified enzyme, bead-bound immunocomplex, etc.). Deacetylation of the substrate sensitizes the substrate so that, in a second step, treatment with the Fluor de Lys® Developer produces a fluorophore. Histone deacetylases from all known classes have been successfully assayed with the Fluor de Lys® Substrate. These include human HDACs 1, 2, 3 and 8 (class I), human HDACs 4 and 9 (class II) and the sirtuins yeast Sir2, human SIRT1 and human SIRT2 (class III; reaction must include the sirtuin substrate NAD+). The substrate is cell-permeable and serves as the basis for the HDAC Cellular Activity Assay Kit (Prod. No. BML-AK503). NOTE: Must be used in conjunction with Fluor de Lys® Developer (Prod. No. BML-KI105). Sufficient for 100-1000 assays of HDACs or sirtuins (50 µl reaction volume, 50-500 µM (substrate).
UOM: 1 * 50 µl
Image Unavailable-ENZOBMLAK5160001

FLUOR DE LYS® HDAC6 fluorometric drug discovery kit

Catalog Number: (ENZOBMLAK5160001)
Supplier: ENZO LIFE SCIENCES
Description: A Fluor-de-Lys® fluorescent assay system. The HDAC6 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC6 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions. The Fluor de Lys® HDAC6 assay is based on the Fluor de Lys® Substrate and Fluor de Lys® Developer combination. The assay procedure has two steps. First, the Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with HDAC6. Deacetylation of the substrate sensitizes the substrate so that, in the second step, treatment with the Fluor de Lys®Developer produces a fluorophore.
UOM: 1 * 1 KIT
Image Unavailable-ANTIA305219-100

Anti-Acetylated Lysine Rabbit Polyclonal Antibody

Catalog Number: (ANTIA305219-100)
Supplier: ANTIBODIES.COM
Description: Anti-Acetylated Lysine Rabbit Polyclonal Antibody
UOM: 1 * 100 µG

New Product


Image Unavailable-ENZOBMLAK5180001

FLUOR DE LYS® HDAC8 fluorometric drug discovery kit

Catalog Number: (ENZOBMLAK5180001)
Supplier: ENZO LIFE SCIENCES
Description: A Fluor-de-Lys® fluorescent assay system. The HDAC8 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC8 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions. The Fluor de Lys® HDAC8 assay is based on the Fluor de Lys® Substrate and Fluor de Lys® Developer combination. The assay procedure has two steps. First, the Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with HDAC6. Deacetylation of the substrate sensitizes the substrate so that, in the second step, treatment with the Fluor de Lys®Developer produces a fluorophore.
UOM: 1 * 1 KIT
Image Unavailable-BOSSBS-7803R

Anti-HCFC1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-7803R)
Supplier: Bioss
Description: Involved in control of the cell cycle. Also antagonizestransactivation by ZBTB17 and GABP2; represses ZBTB17 activation ofthe p15(INK4b) promoter and inhibits its ability to recruit p300.Coactivator for EGR2 and GABP2. Tethers the chromatin modifyingSet1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3histone deacetylase (HDAC) complexes (involved in the activationand repression of transcription, respectively) together. Componentof a THAP1/THAP3-HCFC1-OGT complex that is required for theregulation of the transcriptional activity of RRM1. As part of theNSL complex it may be involved in acetylation of nucleosomalhistone H4 on several lysine residues. In case of human herpessimplex virus (HSV) infection, HCFC1 forms a multiprotein-DNAcomplex with the viral transactivator protein VP16 and POU2F1thereby enabling the transcription of the viral immediate earlygenes.
UOM: 1 * 100 µl
Product Image-AATB13601

Amplite® Fluorimetric HDAC Activity Assay Kit *Green Fluorescence*

Catalog Number: (AATB13601)
Supplier: AAT BIOQUEST
Description: Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups from a ε-N-acetyl lysine amino acid on a histone.
UOM: 1 * 200 Tests
Image Unavailable-ABNOPAB5854

Anti-ACK Polyclonal Antibody

Catalog Number: (ABNOPAB5854)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against Acetylated Lysine.
UOM: 1 * 100 µG
Product Image-ABNOPAB10348

Anti-ACK Polyclonal Antibody

Catalog Number: (ABNOPAB10348)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against Acetylated lysine.
UOM: 1 * 100 µG
Product Image-ABNOPAB0651

Anti-Histone H3 (K9ac) Rabbit Polyclonal Antibody

Catalog Number: (ABNOPAB0651)
Supplier: Abnova
Description: Rabbit polyclonal antibody raised against synthetic peptide of histone H3 (acetylated lysine 9).
UOM: 1 * 50 µG
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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