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Image Unavailable-BOSSBS-5046R-CY7

Anti-CYP46A1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-5046R-CY7)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12324R-HRP

Anti-PTCHD2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-12324R-HRP)
Supplier: Bioss
Description: PTCHD2 is a 1,392 amino acid multi-pass membrane protein that contains one SSD (sterol-sensing) domain and belongs to the patched family. Expressed in retina, brain and testis, PTCHD2 localizes to endoplasmic reticulum and colocalizes with cholesterol. PTCHD2 overexpression leads to increased cholesterol levels, suggesting that PTCHD2 may play a role in cholesterol homeostasis. PTCHD2 is further hypothesized to act as a link between thyroid hormone and cholesterol metabolism. Existing as two alternatively spliced isoforms, PTCHD2 is thought to assist in the release of lipid-anchored secreted proteins and is encoded by a gene that maps to human chromosome 1p36.22.
UOM: 1 * 100 µl

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Image Unavailable-BOSSBS-12324R-A680

Anti-PTCHD2/DISP3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-12324R-A680)
Supplier: Bioss
Description: PTCHD2 is a 1392 amino acid multi-pass membrane protein that contains one SSD (sterol-sensing) domain and belongs to the patched family. Expressed in retina, brain and testis, PTCHD2 localizes to endoplasmic reticulum and colocalizes with cholesterol. PTCHD2 overexpression leads to increased cholesterol levels, suggesting that PTCHD2 may play a role in cholesterol homeostasis. PTCHD2 is further hypothesized to act as a link between thyroid hormone and cholesterol metabolism. Existing as two alternatively spliced isoforms, PTCHD2 is thought to assist in the release of lipid-anchored secreted proteins and is encoded by a gene that maps to human chromosome 1p36.22.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6560R-CY7

Anti-OSBP2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-6560R-CY7)
Supplier: Bioss
Description: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6560R-A350

Anti-OSBP2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-6560R-A350)
Supplier: Bioss
Description: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6560R-FITC

Anti-OSBP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-6560R-FITC)
Supplier: Bioss
Description: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12501R-A555

Anti-APOM Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-12501R-A555)
Supplier: Bioss
Description: Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel ∫ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre∫-HDL formation. Pre∫-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5046R-HRP

Anti-CYP46A1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-5046R-HRP)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5046R-FITC

Anti-CYP46A1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-5046R-FITC)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5046R-A647

Anti-CYP46A1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-5046R-A647)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5051R-A647

Anti-CYP46A1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-5051R-A647)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5046R-A750

Anti-CYP46 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-5046R-A750)
Supplier: Bioss
Description: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain.Cyp46 is also known as 24S-cholesterol hydroxylase.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1698R-A488

Anti-ox-LDL Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-1698R-A488)
Supplier: Bioss
Description: Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1698R-A555

Anti-ox-LDL Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-1698R-A555)
Supplier: Bioss
Description: Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1698R-CY3

Anti-ox-LDL Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-1698R-CY3)
Supplier: Bioss
Description: Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearence of cholesterol from the circulation. In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. Low-density lipoprotein oxidised with Cu2SO4.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6480R-FITC

Anti-CH25H Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-6480R-FITC)
Supplier: Bioss
Description: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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