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Image Unavailable-BOSSBS-13025R-A488

Anti-TRDMT1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-13025R-A488)
Supplier: Bioss
Description: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
UOM: 1 * 100 µl
Product Image-AATB2223

Tide Quencher™ 3 CPG 500 Å, Tide Quencher™ fluorescent probe

Catalog Number: (AATB2223)
Supplier: AAT BIOQUEST
Description: TQ3 is designed to be a superior quencher to TAMRA, TF3 and Cy3.
UOM: 1 * 100 mg
Image Unavailable-USBIM2472-03B

Anti-MBD2 Goat Polyclonal Antibody

Catalog Number: (USBIM2472-03B)
Supplier: US Biological
Description: Anti-MBD2 Goat Polyclonal Antibody
UOM: 1 * 100 µG
Product Image-EM0821

CpG methyltransferase

Catalog Number: (EM0821)
Supplier: Thermo Fisher Scientific
Description: CpG methyltransferase enzyme methylates the C5 position on the base moiety of all cytosine nucleotides contained in unmethylated or hemimethylated double stranded DNA in a 5'-CpG-3' context. Thermo Scientific M.SssI is specifically formulated for fast reaction times without compromising the reaction efficiency. The enzyme completes modification of all CpGs in 15 minutes at 37 °C. In addition, the enzyme has been specifically validated for use with genomic DNA – the primary substrate in epigenetic studies.
UOM: 1 * 1 KIT
Product Image-USBI038234-PE

Anti-MBD3 Rabbit Polyclonal Antibody (PE (Phycoerythrin))

Catalog Number: (USBI038234-PE)
Supplier: US Biological
Description: Anti-MBD3 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM: 1 * 200 µl
Product Image-AATB2194

Tide Quencher™ 1 CPG 1000 Å, Tide Quencher™ fluorescent probe

Catalog Number: (AATB2194)
Supplier: AAT BIOQUEST
Description: TQ1 is designed to be a superior quencher alternative to DABCYL.
UOM: 1 * 100 mg
Product Image-AATB2240

Tide Fluor™ 1 CPG 500 Å, Tide Fluor™ fluorescent probe

Catalog Number: (AATB2240)
Supplier: AAT BIOQUEST
Description: TF1 is designed to be a superior fluorophore alternative to EDANS.
UOM: 1 * 100 mg
Image Unavailable-AATB2085

5.1 CPG [TQ5.1 CPG], Tide Quencher™ 1000 Å

Catalog Number: (AATB2085)
Supplier: AAT BIOQUEST
Description: Tide Quencher™ 5.1 (TQ5.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy5, Cy5.5, Alexa Fluor® 647, Alexa Fluor® 647, iFluor® 647 and iFluor® 680.
UOM: 1 * 100 mg

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Image Unavailable-AATB2116

7.1 CPG [TQ7.1 CPG], Tide Quencher™ (500 A)

Catalog Number: (AATB2116)
Supplier: AAT BIOQUEST
Description: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
UOM: 1 * 100 mg

New Product


Image Unavailable-BOSSBS-5915R

Anti-MBD1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-5915R)
Supplier: Bioss
Description: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
UOM: 1 * 100 µl
Image Unavailable-AATB2428

AzoDye-2 CPG 1000 A (500 A)

Catalog Number: (AATB2428)
Supplier: AAT BIOQUEST
Description: AzoDye-2 CPG is an excellent building block for preparing FRET oligo molecules.
UOM: 1 * 100 mg

New Product


Image Unavailable-BSENR-1810-100

Anti-MECP2 Rabbit Polyclonal Antibody

Catalog Number: (BSENR-1810-100)
Supplier: Biosensis
Description: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Ref: uniprot.org
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-13025R-FITC

Anti-TRDMT1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-13025R-FITC)
Supplier: Bioss
Description: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13025R-CY5

Anti-TRDMT1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-13025R-CY5)
Supplier: Bioss
Description: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
UOM: 1 * 100 µl
Image Unavailable-AATB2117

7.1 CPG [TQ7.1 CPG], Tide Quencher™ 1000 Å

Catalog Number: (AATB2117)
Supplier: AAT BIOQUEST
Description: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
UOM: 1 * 100 mg

New Product


Image Unavailable-AATB2124

7.2 CPG [TQ7.2 CPG], Tide Quencher™ (500 A)

Catalog Number: (AATB2124)
Supplier: AAT BIOQUEST
Description: Tide Quencher™ 7.2 (TQ7.2) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
UOM: 1 * 100 mg

New Product


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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