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Image Unavailable-BSENR-1810-100

Anti-MECP2 Rabbit Polyclonal Antibody

Description: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Ref: uniprot.org
Catalog Number: BSENR-1810-100
UOM: 1 * 100 µG
Supplier: Biosensis
Product Image-HAMI80342

GC autosampler syringes for Bruker Varian Chrompack

Description: These GC syringes are suitable for Bruker Varian Chrompack autosamplers.
Catalog Number: HAMI80342
UOM: 1 * 1 items
Supplier: HAMILTON BONADUZ
Image Unavailable-AATB2116

7.1 CPG [TQ7.1 CPG], Tide Quencher™ (500 A)

Description: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
Catalog Number: AATB2116
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Product Image-HAMICAL84851

Microliter™ 800 series syringes

Description: Universal injection syringes for GC. Similar to the 700 series but with a reinforced, protected plunger.
Catalog Number: HAMICAL84851
UOM: 1 * 1 items
Supplier: HAMILTON BONADUZ
Image Unavailable-AATB2428

AzoDye-2 CPG 1000 A (500 A)

Description: AzoDye-2 CPG is an excellent building block for preparing FRET oligo molecules.
Catalog Number: AATB2428
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Image Unavailable-BOSSBS-5915R

Anti-MBD1 Rabbit Polyclonal Antibody

Description: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Catalog Number: BOSSBS-5915R
UOM: 1 * 100 µl
Supplier: Bioss
Product Image-EM0821

CpG methyltransferase

Description: CpG methyltransferase enzyme methylates the C5 position on the base moiety of all cytosine nucleotides contained in unmethylated or hemimethylated double stranded DNA in a 5'-CpG-3' context. Thermo Scientific M.SssI is specifically formulated for fast reaction times without compromising the reaction efficiency. The enzyme completes modification of all CpGs in 15 minutes at 37 °C. In addition, the enzyme has been specifically validated for use with genomic DNA – the primary substrate in epigenetic studies.
Catalog Number: EM0821
UOM: 1 * 1 KIT
Supplier: Thermo Fisher Scientific
Image Unavailable-BOSSBS-13009R

Anti-DMAP1 Rabbit Polyclonal Antibody

Description: Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo.
Catalog Number: BOSSBS-13009R
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-AATB2117

7.1 CPG [TQ7.1 CPG], Tide Quencher™ 1000 Å

Description: Tide Quencher™ 7.1 (TQ7.1) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
Catalog Number: AATB2117
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Image Unavailable-AATB2124

7.2 CPG [TQ7.2 CPG], Tide Quencher™ (500 A)

Description: Tide Quencher™ 7.2 (TQ7.2) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
Catalog Number: AATB2124
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Image Unavailable-AATB2125

7.2 CPG [TQ7.2 CPG], Tide Quencher™ 1000 Å

Description: Tide Quencher™ 7.2 (TQ7.2) is a non-fluorescent molecule designed to efficiently quench the fluorescence of common NIR fluorophores such as Cy7, Alexa Fluor® 700, Alexa Fluor® 750, iFluor® 700, iFluor® 710, iFluor® 720 and iFluor® 750.
Catalog Number: AATB2125
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Image Unavailable-BOSSBS-13025R-CY7

Anti-TRDMT1 Rabbit Polyclonal Antibody (Cy7®)

Description: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
Catalog Number: BOSSBS-13025R-CY7
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-5915R-A750

Anti-MBD1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Description: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalise with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both <i>in vivo</i> and <i>in vitro</i>. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
Catalog Number: BOSSBS-5915R-A750
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-AATB2478

AzoDye-3 CPG 1000 A (500 A)

Description: AzoDye-3 CPG is an excellent building block for preparing FRET oligo molecules.
Catalog Number: AATB2478
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST

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Image Unavailable-USBI038242-FITC

Anti-MBD4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: Anti-MBD4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
Catalog Number: USBI038242-FITC
UOM: 1 * 200 µl
Supplier: US Biological
Product Image-AATB2204

Tide Quencher™ 2 CPG 1000 Å, Tide Quencher™ fluorescent probe

Description: TQ2 is designed to be a superior quencher to FAM, HEX, TET, JOE, TF2 and rhodamine 6G.
Catalog Number: AATB2204
UOM: 1 * 100 mg
Supplier: AAT BIOQUEST
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