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Description: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Catalog Number: BOSSBS-6792R-A555
UOM: 1 * 100 µl
Supplier: Bioss


Description: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Catalog Number: BOSSBS-6792R-A647
UOM: 1 * 100 µl
Supplier: Bioss


Description: These sumps are manufactured from high quality polyethylene (HD-LMD).
Catalog Number: CEMG8524
UOM: 1 * 1 items
Supplier: CEMO


Description: Ultrasonic bath accessories, Insert tub, KW 10-0, plastic with cap, dimensions 242×182×135 mm, For: SUPER RK 510 / H, DIGITEC DT 510 H / H-RC
Catalog Number: BAND3053
UOM: 1 * 1 items
Supplier: BANDELIN-ELECTRONIC


Description: PP, highly translucent.
Catalog Number: 213-3735
UOM: 1 * 1 items
Supplier: VITLAB


Description: Thes filters with stems are 100% 316 stainless steel. Filters with threaded fittings have threaded Kel-F® (PCTFE) caps.
Catalog Number: 554-5769
UOM: 1 * 1 items
Supplier: UPCHURCH SCIENTIFIC


Description: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
Catalog Number: BOSSBS-9140R-CY5
UOM: 1 * 100 µl
Supplier: Bioss


Description: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.
Catalog Number: BOSSBS-9140R-A555
UOM: 1 * 100 µl
Supplier: Bioss


Description: PP, highly translucent.
Catalog Number: 213-0263
UOM: 1 * 1 items
Supplier: VITLAB


Description: PP, highly translucent.
Catalog Number: HIRS7600296
UOM: 1 * 6 items
Supplier: HIRSCHMANN


Description: PP, highly transparent.
Catalog Number: BURK7104-3000
UOM: 1 * 1 items
Supplier: BURKLE


Description: SAN, crystal clear.
Catalog Number: VITL44491
UOM: 1 * 1 items
Supplier: VITLAB


Description: PMMA protection shield, transparent, thickness: 5 mm, provides laboratory and healthcare personnel with facial protection from hazardous substances, aerosol and splashing.
Catalog Number: KART571
UOM: 1 * 1 items
Supplier: KARTELL


Description: These mixed standards are ready to use, no dilutions are required. They contain BOD, COD and TOC.
Catalog Number: HACH2833510
UOM: 1 * 1 Each
Supplier: Hach

Description: Anti-CSAG2 Rabbit Polyclonal Antibody
Catalog Number: USBI034265
UOM: 1 * 200 µl
Supplier: US Biological


Description: The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Catalog Number: BOSSBS-6792R-A350
UOM: 1 * 100 µl
Supplier: Bioss


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